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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

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Related Experiment Video

Updated: Jun 28, 2026

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

Predicting progressive glaucomatous optic neuropathy using baseline standard automated perimetry data.

Shaban Demirel1, Brad Fortune, Juanjuan Fan

  • 1Devers Eye Institute, Legacy Health System, Portland, Oregon 97232, USA. sdemirel@deverseye.org

Investigative Ophthalmology & Visual Science
|October 22, 2008
PubMed
Summary

Specific visual field patterns can predict progressive glaucomatous optic neuropathy (pGON) in high-risk patients. These spatial findings offer valuable insights even with early-stage visual field changes.

Related Experiment Videos

Last Updated: Jun 28, 2026

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
07:11

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential

Published on: May 25, 2020

Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Biostatistics

Background:

  • Glaucoma is a leading cause of irreversible blindness.
  • Early detection of progressive glaucomatous optic neuropathy (pGON) is crucial for timely intervention.
  • Standard automated perimetry (SAP) is a key tool for glaucoma assessment.

Purpose of the Study:

  • To evaluate if specific visual field locations and patterns predict the development of pGON.
  • To assess the predictive capability of baseline visual field data for future glaucoma progression.

Main Methods:

  • A classification tree model was developed using baseline data from 168 individuals with ocular hypertension or early glaucoma.
  • Predictors included age-adjusted SAP thresholds and other clinical variables.
  • pGON was determined using longitudinal stereo optic nerve head photographs.

Main Results:

  • Classification tree models demonstrated that visual field patterns predict pGON with an average sensitivity of 65% and specificity of 87%.
  • Models showed an average specificity of 69% when tested with data from 100 normal subjects.

Conclusions:

  • Classification trees effectively identify visual field locations most predictive of pGON.
  • Spatial patterns in visual fields provide significant predictive information, even when thresholds are within normal ranges.