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Related Experiment Video

Updated: Jun 28, 2026

Standardized Hemorrhagic Shock Induction Guided by Cerebral Oximetry and Extended Hemodynamic Monitoring in Pigs
07:51

Standardized Hemorrhagic Shock Induction Guided by Cerebral Oximetry and Extended Hemodynamic Monitoring in Pigs

Published on: May 21, 2019

Continuous hemofiltration in pigs with hyperdynamic septic shock affects cardiac repolarization.

Milan Stengl1, Roman Sykora, Ales Krouzecky

  • 1Department of Physiology, Charles University in Prague, Faculty of Medicine and Teaching Hospital in Plzen, Plzen, Czech Republic. milan.stengl@lfp.cuni.cz

Critical Care Medicine
|October 22, 2008
PubMed
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Sepsis and hemofiltration shorten cardiac repolarization duration in pigs. Continuous hemofiltration did not increase arrhythmia risk, and inflammatory mediators did not cause repolarization changes.

Area of Science:

  • Cardiovascular Physiology
  • Critical Care Medicine
  • Renal Replacement Therapy

Background:

  • Sepsis involves complex inflammatory responses that can affect cardiac function.
  • Continuous hemofiltration is explored for removing inflammatory mediators in sepsis.
  • Previous studies suggest hemodialysis and hemofiltration may impact cardiac electrophysiology and increase arrhythmia risk.

Purpose of the Study:

  • To investigate the effects of sepsis on cardiac electrophysiologic properties in a porcine model.
  • To determine how continuous hemofiltration modifies the electrophysiologic effects of sepsis.
  • To test the hypothesis that sepsis and hemofiltration alter cardiac repolarization.

Main Methods:

  • Laboratory animal experiments using a porcine model of sepsis induced by fecal peritonitis.

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Standardized Model of Ventricular Fibrillation and Advanced Cardiac Life Support in Swine
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Related Experiment Videos

Last Updated: Jun 28, 2026

Standardized Hemorrhagic Shock Induction Guided by Cerebral Oximetry and Extended Hemodynamic Monitoring in Pigs
07:51

Standardized Hemorrhagic Shock Induction Guided by Cerebral Oximetry and Extended Hemodynamic Monitoring in Pigs

Published on: May 21, 2019

Standardized Model of Ventricular Fibrillation and Advanced Cardiac Life Support in Swine
05:36

Standardized Model of Ventricular Fibrillation and Advanced Cardiac Life Support in Swine

Published on: January 30, 2020

  • Anesthetized, mechanically ventilated pigs underwent 22 hours of sepsis, with conventional or high-volume hemofiltration during the final 10 hours.
  • Electrocardiograms and action potentials in isolated ventricular tissues were recorded; plasma cytokine levels were measured.

    • Main Results:

    • Sepsis significantly shortened RR, QT, and QTc intervals and action potential durations.
    • High-volume hemofiltration partially blunted the increase in tumor necrosis factor-alpha.
    • Both hemofiltration methods further shortened action potential durations, which were reversed by septic hemofiltrates; TNF-alpha alone had no effect.

    Conclusions:

    • Sepsis and continuous hemofiltration shorten cardiac repolarization duration in a porcine model of septic shock.
    • Continuous hemofiltration was not associated with an increased risk of ventricular arrhythmias.
    • Interleukin-6 and tumor necrosis factor-alpha were not found to be the primary mediators of the observed changes in action potential durations.