Related Experiment Video
Updated: Aug 10, 2026

The Dimethylnitrosamine Induced Liver Fibrosis Model in the Rat
Published on: June 17, 2016
The fate of trimethylamine in the rat
1Department of Pharmacology and Toxicology, St. Mary's Hospital Medical School, Paddington, London, England.
Abstract:
The metabolism and excretion of [14C]-trimethylamine has been investigated in seven strains of rat. Over 75% of the administered radioactivity was excreted via the urine within the first day, with up to 9% in the faeces. At this dose level (15 mg/kg body wt) N-oxidation was the major metabolic pathway encountered (45% excreted dose) whilst demethylation was only of minor importance (3%). The remaining compound was excreted unchanged. No significant differences were observed between the strains studied.
More Related Videos
11:01Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase
Published on: November 23, 2016
04:19An Improved Technique for Trimethylamine Detection in Animal-Derived Medicine by Headspace Gas Chromatography-Tandem Quadrupole Mass Spectrometry
Published on: March 10, 2023
Related Concept Videos
2° Amines to N-Nitrosamines: Reaction with NaNO2
Physical Properties of Amines
Toxicity Testing in Animals