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Related Concept Videos

Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
Protein Organization01:13

Protein Organization

Overview
Protein Organization01:13

Protein Organization

Overview
Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
Protein Folding01:22

Protein Folding

Overview
Protein Folding01:22

Protein Folding

Overview

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Updated: Jun 28, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

Knowledge-based computational intelligence development for predicting protein secondary structures from sequences.

Hong-Bin Shen1, Dong-Liang Yi, Li-Xiu Yao

  • 1Institute of Image Processing & Pattern Recognition, Shanghai Jiaotong University, 800 Dongchuan Road, Shanghai, 200240, China. hbshen@sjtu.edu.cn

Expert Review of Proteomics
|October 22, 2008
PubMed
Summary

Automated methods for predicting protein secondary structures are crucial due to vast sequence data. This review highlights progress in computational intelligence for membrane proteins, a challenging area.

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Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

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Area of Science:

  • Structural bioinformatics
  • Computational biology
  • Biochemistry

Background:

  • The postgenomic era yields numerous protein sequences, outpacing experimental structure determination.
  • Membrane proteins constitute ~30% of all proteins but <1% of solved structures.
  • Accurate protein structure prediction is vital for understanding function.

Purpose of the Study:

  • To review recent advancements in automated protein secondary structure prediction methodologies.
  • To focus on the specific challenges and progress related to membrane proteins.
  • To identify future research directions in this field.

Main Methods:

  • Review of computational intelligence techniques applied to protein secondary structure prediction.
  • Analysis of methodologies specifically developed or adapted for membrane proteins.
  • Synthesis of current literature on automated structure prediction.

Main Results:

  • Significant progress has been made in computational methods for predicting secondary structures.
  • Specialized techniques are emerging for the accurate prediction of membrane protein secondary structures.
  • The review consolidates current methodologies and their effectiveness.

Conclusions:

  • Automated prediction of protein secondary structures, particularly for membrane proteins, remains an active and challenging research area.
  • Continued development of computational intelligence is essential for advancing structural bioinformatics.
  • Future work should focus on improving accuracy and addressing the unique properties of membrane proteins.