Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Multiple Allele Traits01:49

Multiple Allele Traits

The Concept of Multiple Allelism
Genetic Variation01:25

Genetic Variation

Genetic variation is the diversity in DNA sequences found among individuals of the same species. This diversity is crucial for a species' survival because it helps organisms adapt to environmental changes. Genetic variation begins with fertilization, where an egg and sperm cell merge. Each of these cells carries 23 chromosomes, up to 46 in the fertilized egg. Chromosomes are long DNA strands that contain genes, the basic units of heredity.
Genes exist in different versions called alleles, which...
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Principles of Pharmacogenetics: Types of Genetic Variants01:27

Principles of Pharmacogenetics: Types of Genetic Variants

The human genome is over 99.9% identical between individuals, yet genetic differences exist at millions of bases. The human genome contains approximately 3 million variant positions per individual, many of which are heterozygous, contributing to genetic diversity and individual traits. Genetic variations include single-nucleotide polymorphisms (SNPs), insertions, deletions, and copy number variations (CNVs).SNPs, the most common variation, involve single-base changes in DNA. These can be...
Genetic Lingo01:11

Genetic Lingo

Overview
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Airway management in thoracic surgery in a patient with right tracheal supernumerary bronchus.

Revista espanola de anestesiologia y reanimacion·2025
Same author

[Roth spots and perivascular infiltrates secondary to chronic myelocytic leukemia].

Journal francais d'ophtalmologie·2023
Same author

Correction: Improving time-resolution and sensitivity of <i>in situ</i> X-ray photoelectron spectroscopy of a powder catalyst by modulated excitation.

Chemical science·2023
Same author

[Iris pigment epithelial cyst dislocated into the vitreous].

Journal francais d'ophtalmologie·2023
Same author

Improving time-resolution and sensitivity of <i>in situ</i> X-ray photoelectron spectroscopy of a powder catalyst by modulated excitation.

Chemical science·2023
Same author

Evaluating the effectiveness of a single-day simulation-based program in psychiatry for medical students: a controlled study.

BMC medical education·2021

Related Experiment Video

Updated: Jun 28, 2026

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
08:07

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Published on: September 6, 2017

Characterisation of five novel HLA-G alleles with coding DNA base changes.

J Lajoie1, A Jeanneau, M-C Faucher

  • 1Laboratoire d'immunogénétique, Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Québec, Canada.

Tissue Antigens
|October 22, 2008
PubMed
Summary

Researchers discovered five new human leukocyte antigen-G (HLA-G) alleles. These alleles contain mutations that alter protein function, identified in Caucasian and African populations.

More Related Videos

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens
09:53

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens

Published on: February 6, 2017

Related Experiment Videos

Last Updated: Jun 28, 2026

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
08:07

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

Published on: September 6, 2017

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens
09:53

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens

Published on: February 6, 2017

Area of Science:

  • Immunogenetics
  • Molecular Biology

Background:

  • Human leukocyte antigen-G (HLA-G) is a non-classical MHC class I molecule with crucial roles in immune tolerance.
  • Polymorphisms in HLA-G can influence immune responses and disease susceptibility.

Purpose of the Study:

  • To identify novel human leukocyte antigen-G (HLA-G) alleles.
  • To characterize protein-modifying mutations within these newly identified alleles.

Main Methods:

  • High-throughput sequencing of HLA-G genes.
  • Bioinformatic analysis to identify sequence variations.
  • In silico prediction of protein structure and function alterations.

Main Results:

  • Identification of five previously undescribed HLA-G alleles.
  • Detection of several novel single nucleotide polymorphisms (SNPs) leading to amino acid changes.
  • Mutations were found in both Caucasian and African population cohorts.

Conclusions:

  • The discovery of novel HLA-G alleles expands our understanding of HLA-G genetic diversity.
  • These protein-modifying mutations may have functional implications for immune regulation and transplantation outcomes.