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[Importance of HLA-G in therapy of cancer]

Inès Zidi1, Aghleb Bartegi

  • 1Laboratoire de Biochimie, Institut Supérieur de Biotechnologie de Monastir, Avenue Tahar Haddad, Monastir, Tunisia. ines.zidi@techemail.com

Therapie
|October 22, 2008
PubMed

HLA-G (Human Leucocyte Antigen-G) is a non-classical HLA class I molecule observed for the first time in human cytotrophoblast. Numbers of investigations have demonstrated that HLA-G was broader than originally thought. In fact, it is expressed in pathological contexts as well as in physiological contexts. This expression of HLA-G and its receptors in immunity cells confer to it a major role in immune responses. Good issues were described in organ transplantation when HLA-G was expressed. But, HLA-G transcripts and/or proteins expression in tumor tissues was associated with tumor genesis and cancer progression. A focus on the expression and the role of HLA-G in tumor context will be developed in this review. In addition, regulation of HLA-G will be treated to improve strategies of cancer therapy.

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