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Related Concept Videos

Type I Diabetes III: Clinical Manifestations01:19

Type I Diabetes III: Clinical Manifestations

Type 1 diabetes mellitus typically presents with rapid-onset symptoms due to the body’s inability to utilize glucose in the absence of insulin. Since insulin is required for glucose uptake into cells, its deficiency leads to hyperglycemia and cellular energy deprivation, resulting in characteristic clinical features.Polyuria and PolydipsiaOne of the earliest, most prominent symptoms is polyuria (excessive urination). When blood glucose concentrations rise above the renal threshold, the kidneys...
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Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1 diabetes is an...
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Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

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Robotic Enucleation of an Intra-Pancreatic Insulinoma in the Pancreatic Head
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Published on: January 3, 2020

[Giant insulinoma].

S Ketari-Jamoussi1, A Debbiche-Chedly, B Ben Dhaou

  • 1Service de médecine interne, hôpital Habib-Thameur, Montfleury, Tunis 1008, Tunisie. s.ktari@mailcity.com

Annales D'Endocrinologie
|October 22, 2008
PubMed
Summary
This summary is machine-generated.

This case study highlights a rare giant insulinoma, a pancreatic neuroendocrine tumor, presenting unusually with pseudo-polycythemia. Early diagnosis of such rare tumors is crucial for effective treatment.

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Area of Science:

  • Endocrinology
  • Oncology
  • Gastroenterology

Background:

  • Islet-cell tumors are common pancreatic neuroendocrine tumors, usually benign and sporadic.
  • Diagnosis is often delayed due to non-specific clinical signs.
  • Insulinomas are typically small (<2cm), making localization challenging.

Observation:

  • An 80-year-old man presented with pseudo-polycythemia, initially mistaken for Vaquez disease.
  • He also experienced nocturnal agitation and presented with reddish skin and a suspected enlarged spleen.
  • Imaging revealed a large tumor between the pancreas and spleen.

Findings:

  • The tumor was confirmed as an insulinoma by elevated proinsulin levels during asymptomatic hypoglycemia.
  • Histopathology revealed a malignant, well-differentiated neuroendocrine tumor.
  • The patient underwent splenopancreatectomy.

Implications:

  • Giant insulinomas are rare and can present with atypical symptoms like pseudo-polycythemia.
  • This case underscores the importance of considering rare diagnoses in the presence of unusual clinical presentations.
  • Advanced imaging and biochemical markers are vital for diagnosing and localizing small or large insulinomas.