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Respiratory Syncytial Virus Disease

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...

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Coronavirus

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Coronaviruses, including the severe acute respiratory syndrome coronavirus (SARS-CoV), are enveloped viruses characterized by their single-stranded, positive-sense RNA genome and helical nucleocapsid structure. The hallmark of these viruses is their club-shaped spike (S) glycoproteins that protrude from the viral envelope, facilitating attachment to host cells. Typically, coronaviruses infect the upper respiratory tract, often causing mild or asymptomatic disease. However, certain strains like...

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Updated: Jun 28, 2026

Protocol for Recombinant RBD-based SARS Vaccines: Protein Preparation, Animal Vaccination and Neutralization Detection

Protocol for Recombinant RBD-based SARS Vaccines: Protein Preparation, Animal Vaccination and Neutralization Detection

Published on: May 2, 2011

[SARS vaccines].

Fumihiro Taguchi¹

¹Department of Virology III, National Institute of Infectious Diseases.

Nihon Rinsho. Japanese Journal of Clinical Medicine

|October 23, 2008

Summary

Severe acute respiratory syndrome (SARS) is a dangerous emerging disease caused by a novel coronavirus. While various vaccines show promise in animals, none are yet safe and effective for human use.

Area of Science:

Virology
Immunology
Emerging Infectious Diseases

Context:

Severe acute respiratory syndrome (SARS) is a highly pathogenic emerging disease with significant mortality, caused by a novel coronavirus.
Research efforts have focused on developing prophylactic and therapeutic strategies against SARS, utilizing laboratory animal models.

Purpose:

To review the current landscape of SARS vaccine development and identify key challenges.
To highlight the importance of neutralizing antibodies in protective immunity against SARS-CoV.

Summary:

Multiple vaccine platforms, including inactivated virus, subunit, DNA, viral vector, and live attenuated vaccines, have been explored for SARS.
These studies consistently demonstrate the critical role of neutralizing antibodies in conferring protection against SARS-CoV infection.

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Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection

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Despite extensive research, a safe and highly effective human vaccine for SARS remains elusive.

Impact:

This review underscores the urgent need for continued research into novel vaccine candidates and delivery systems for SARS.
Understanding the immunological mechanisms of protection is crucial for designing future SARS vaccines.
The findings have implications for the development of vaccines against other emerging coronaviruses.