Related Experiment Video
Updated: Aug 14, 2026

Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance
Published on: March 21, 2013
New diagnostic modalities for the evaluation of the patient with syncope
1Department of Medicine, Medical Center of Delaware.
Insights
Cardiac syncope patients face poor prognosis and sudden death risk, often due to ventricular tachycardia. Early electrophysiology (EP) testing is crucial for diagnosing cardiac syncope and guiding treatment.
Area of Science:
- Cardiology
- Clinical Electrophysiology
Background:
- Syncope is a frequent clinical issue with significant implications, especially when cardiac in origin.
- Cardiac syncope is associated with a poor prognosis and increased risk of sudden cardiac death.
- Ventricular tachycardia in coronary artery disease is a common cause of cardiac syncope.
Purpose of the Study:
- To outline diagnostic strategies for syncope, differentiating cardiac from non-cardiac causes.
- To emphasize the importance of electrophysiology (EP) testing in patients with structural heart disease and syncope.
- To highlight the utility of specific tests like SAE and tilt testing in syncope evaluation.
Main Methods:
- Review of diagnostic approaches for syncope.
- Emphasis on EP testing for patients with syncope and structural heart disease.
- Discussion of the role of the Syncope Assessment Engine (SAE) and tilt testing.
- Recommendation for loop monitoring in undiagnosed cases.
Main Results:
- Patients with cardiac syncope have a poor prognosis and high sudden death incidence.
- Ventricular tachycardia is a primary concern in coronary artery disease patients with syncope.
- Syncope in patients with normal hearts often indicates neurally mediated syncope, diagnosable by tilt testing.
- Approximately 30% of patients with syncope and a normal heart experience recurrent episodes.
Conclusions:
- EP testing is essential for patients with syncope and structural heart disease to rule out ventricular tachycardia.
- SAE may aid in identifying patients likely to have ventricular tachycardia at EP testing.
- Neurally mediated syncope is common in patients with normal hearts and can be diagnosed with tilt testing.
- Loop monitoring is recommended for syncope cases that remain undiagnosed after initial evaluation.
Abstract:
Syncope is a common clinical problem. Patients with cardiac syncope have a poor prognosis and a high incidence of sudden death during follow-up. The most common diagnosis in these patients is ventricular tachycardia in the setting of coronary artery disease. Patients with syncope and structural heart disease should undergo EP testing to exclude ventricular tachycardia. The use of SAE may be helpful in selecting patients who are likely to have ventricular tachycardia at EP testing. Patients with syncope and a normal heart have an excellent survival, but about 30 percent have recurrent spells. Those patients with a normal heart and syncope in the upright position often have neurally mediated syncope, and the diagnosis can be confirmed by tilt testing. Patients defying diagnosis should undergo loop monitoring to document the cardiac rhythm during syncope.
Related Concept Videos
Imaging Studies for Cardiovascular System II:Types of Echocardiography
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for diagnosing...
Acute Coronary Syndrome III: Diagnostic Studies
Dysrhythmias V: Evaluating Dysrhythmias
Heart Failure IV: Classification and Diagnostic Evaluation
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
Aneurysm II: Clinical Manifestations and Diagnostic Studies

