Related Experiment Video
Updated: Jun 28, 2026
08:38
Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay (PCA) in Living Cells
Published on: March 3, 2015
STRING 8--a global view on proteins and their functional interactions in 630 organisms
Lars J Jensen1, Michael Kuhn, Manuel Stark
1European Molecular Biology Laboratory, Heidelberg, Germany.
Nucleic Acids Research
|October 23, 2008
Summary
The STRING database provides comprehensive protein-protein interaction data, integrating diverse evidence for over 2.5 million proteins. This resource aids in understanding cellular phenotypes and facilitates biological network modeling.
Area of Science:
- Bioinformatics
- Systems Biology
- Molecular Biology
Background:
- Protein-protein interactions are fundamental to cellular functions and phenotypes.
- Protein interaction networks serve as essential frameworks for biological modeling and data analysis.
Purpose of the Study:
- To present STRING version 8.0, an updated web resource for protein-protein interactions.
- To enhance the comprehensiveness and utility of protein interaction data for researchers.
Main Methods:
- Integration of data from experimental repositories, computational predictions, and text mining.
- Development of a URL-based programming interface for programmatic access.
- Improved prediction algorithms for prokaryotic protein interactions using genomic neighborhood.
Main Results:
- STRING 8.0 covers approximately 2.5 million proteins across 630 organisms.
- Includes both physical and functional protein-protein interaction information.
- Incorporates protein structure data and enhanced prediction methods.
Conclusions:
- STRING 8.0 offers the most extensive view of protein-protein interactions available.
- The database serves as a vital tool for exploring biological networks and understanding cellular mechanisms.
- New features enhance data accessibility and interaction prediction accuracy.
Related Concept Videos
02:26Protein Networks
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
02:26Protein Networks
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
02:04Protein-protein Interfaces
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...
02:04Protein-Protein Interfaces
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...
02:47Protein Families
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02:47Protein Families
Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism. Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members. If these new proteins contain similar amino acids in key locations, protein...