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Updated: Jun 28, 2026

Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis

Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis

Published on: July 19, 2018

Hypercatabolism in dialysis patients.

Dominic S C Raj¹, Yijuan Sun, Antonios H Tzamaloukas

¹Division of Nephrology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico 87131-5271, USA. draj@salud.unm.edu

Current Opinion in Nephrology and Hypertension

|October 23, 2008

Summary

Protein-energy wasting in end-stage renal disease is linked to inflammation and cytokine signaling. Interleukin-6 plays a key role in protein turnover during hemodialysis, impacting nutrient utilization.

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Last Updated: Jun 28, 2026

Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis

Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis

Published on: July 19, 2018

Area of Science:

Nephrology
Metabolic Medicine
Biochemistry

Background:

Protein-energy wasting (PEW) is a significant complication in end-stage renal disease (ESRD).
PEW is characterized by a maladaptive metabolic state often coexisting with inflammation.
Cytokine-adipokine signaling is implicated in the pathogenesis of PEW.

Purpose of the Study:

To review recent advances in protein-energy wasting and protein kinetics in ESRD patients.
To update understanding of the metabolic changes during hemodialysis.

Main Methods:

Review of current literature on protein kinetics and PEW in ESRD.
Analysis of the role of cytokines, particularly Interleukin-6 (IL-6), in protein turnover during hemodialysis.

Main Results:

Hypercatabolism in dialysis patients stems from intradialytic amino acid loss and cytokine activation.
IL-6 regulates whole-body, muscle, and hepatic protein turnover during hemodialysis.
Intradialytic nutrient supplementation enhances protein synthesis but does not reduce muscle protein catabolism.

Conclusions:

IL-6 contributes to intradialytic protein catabolism and impairs amino acid utilization for protein synthesis.
Muscle protein breakdown increases during hemodialysis, but whole-body proteolysis does not, due to amino acid recycling.
Achieving net anabolism requires nutrient provision and inhibition of inflammatory signals.