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Related Experiment Video

Updated: Jun 28, 2026

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles
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Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Published on: March 13, 2017

Simultaneous particle counting and detecting on a chip.

Xudong Wu1, Chan Hee Chon, Yao-Nan Wang

  • 1Department of Biomedical Engineering, Chongqing University, Chongqing, 400044, China.

Lab on a Chip
|October 23, 2008
PubMed
Summary
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This study presents a novel lab-on-a-chip device for simultaneous particle detection and counting using resistive pulse sensing (RPS) and fluorescent detection. The compact system achieves high sensitivity and accuracy, comparable to commercial flow cytometers.

Area of Science:

  • Microfluidics
  • Biotechnology
  • Analytical Chemistry

Background:

  • Accurate particle detection and counting are crucial in various scientific fields.
  • Existing methods often require bulky equipment and complex setups.
  • There is a need for integrated, sensitive, and portable particle analysis systems.

Purpose of the Study:

  • To develop and validate a lab-on-a-chip device for simultaneous particle detection and counting.
  • To integrate resistive pulse sensing (RPS) and fluorescent detection in a single microfluidic platform.
  • To achieve high signal-to-noise ratio and sensitivity for small particle analysis.

Main Methods:

  • A microfluidic chip with a single channel and two detecting arms was designed.
  • Resistive pulse sensing (RPS) was employed for particle number counting.

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Last Updated: Jun 28, 2026

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  • A miniaturized laser-fiber optic system was used for fluorescent particle detection.
  • Two-stage differential amplification was implemented to enhance signal quality.

    • Main Results:

    • The device successfully performed simultaneous RPS and fluorescent detection.
    • High signal-to-noise ratios were achieved for both detection methods.
    • The system demonstrated high sensitivity, detecting 0.9 micrometer fluorescent particles.
    • Results showed excellent agreement with a commercial flow cytometer for mixed particle samples.

    Conclusions:

    • The developed lab-on-a-chip device offers a simple, compact, and sensitive solution for particle analysis.
    • The integrated approach overcomes limitations of traditional methods.
    • This technology has potential for developing portable and cost-effective diagnostic tools.