[Characteristic of bioamine-containing dental pulp structures under normal conditions and in pathology (a luminescence histochemical study)]

Neurotransmitter biogenic amines (BA) are known to be important tissue differentiation inducers and promoters of mutual influence of the epithelial and mesenchymal structures during the process of tooth development in the antenatal period. The aim of this investigation was the study of BA-containing dental pulp structures in the adult humans under normal conditions, and in patients with dental caries and its complications in combination with periodontitis. Using luminescent-histochemical methods, the contents of neurotransmitters (cateholamines, serotonin, histamine) was determined in the dental pulp under normal conditions and in pathology. Qualitative and quantitative changes of BA-containing dental pulp structures are described in patients with dental caries and its complications in combination with periodontitis. It was demonstrated that mast and granular luminescent cells, together with the nerve fibers, were involved in the neurotransmitter control of homeostasis in the dental pulp, both under normal conditions and in pathology, by providing the dental pulp structures with BA. The changes in the content of the neurotransmitter BA were noted already at the stage of initial dental hard tissue lesions and were found to precede the development of an acute pulpitis in combination with intermediate degree periodontitis.