Related Experiment Video
Updated: Jun 28, 2026

A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries
Published on: December 27, 2016
Synthesis and antibiofilm activity of a second-generation reverse-amide oroidin library: a structure-activity
T Eric Ballard1, Justin J Richards, Amanda L Wolfe
1Department of Chemistry, North Carolina State University, Raleigh, NC 27695-8204, USA.
Abstract:
A second-generation library of 2-aminoimidazole-based derivatives incorporating a "reversed amide" (RA) motif in comparison to the marine natural product oroidin were synthesized and subsequently assayed for antibiofilm activity against the medically relevant Gram-negative proteobacteria P. aeruginosa and A. baumannii. Most notably, an in-depth activity profile is reported for the most active subclass of derivatives that bear linear aliphatic chains off the amide bond. Additionally, further structural modifications of the core template, such as removal of the amide bond or substitution with a triazole isostere, resulted in the discovery of analogues with antibiofilm activities that varied with respect to their inhibition and dispersal properties of P. aeruginosa and A. baumannii biofilms.
Related Concept Videos
Inhibitors of Bacterial DNA Synthesis
Antimicrobial Effectiveness
Inhibitors of Bacterial Protein Synthesis
Antifungal Agents
Combined Effects of Drugs: Synergism
Such synergistic combinations...
Inhibitors of Gram-positive Cell Wall Synthesis
