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Related Concept Videos

Nitric Oxide Signaling Pathway01:28

Nitric Oxide Signaling Pathway

Nitric oxide (NO), an inorganic gas, acts as a potent second messenger in most animal and plant tissues. NO diffuses out of the cells that produce it and enters the neighboring cells to generate a downstream response. NO synthase (NOS) catalyzes NO production by the deamination of the amino acid arginine. There are three isoforms of NOS. Endothelial cells have endothelial NOS (eNOS), nerve and muscle cells have neuronal NOS (nNOS), and macrophages produce inducible NOS (iNOS) upon exposure to...

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Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
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Does exogenous nitric oxide influence tympanosclerosis? An experimental study.

Sinan Atmaca1, Yesim Erol, Ahmet Yilmaz Coban

  • 1Department of Otolaryngology and Head and Neck Surgery, Ondokuz Mayis University School of Medicine, Kurupelit 55139, Samsun, Turkey. sinanatmaca@yahoo.com

International Journal of Pediatric Otorhinolaryngology
|October 24, 2008
PubMed
Summary

Exogenous nitric oxide application did not affect tympanosclerosis in a rat model. Further research into cytokine interactions is needed to understand the development of tympanosclerosis.

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Area of Science:

  • Otolaryngology
  • Biomedical Research

Background:

  • Tympanosclerosis is a condition affecting the tympanic membrane.
  • The role of nitric oxide in tympanosclerosis is not fully understood.

Purpose of the Study:

  • To investigate the effect of exogenous nitric oxide on tympanosclerosis.
  • To evaluate nitric oxide's impact on middle ear and tympanic membrane histology.

Main Methods:

  • Myringotomy was performed on 40 male rats.
  • Nitric oxide was applied to the left tympanic cavities, with saline as a control on the right.
  • Otomicroscopic and histologic examinations were conducted three months post-procedure.

Main Results:

  • No significant differences were observed in otomicroscopic or histologic examinations between the nitric oxide and saline groups.
  • Tympanic membrane thickness remained similar on both sides.

Conclusions:

  • Exogenous nitric oxide application did not alter the occurrence of tympanosclerosis in this rat model.
  • Cytokine interactions are likely crucial for initiating the reaction sequence leading to tympanosclerosis.