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Published on: July 11, 2013
Fixed drug eruptions due to cotrimoxazole
M A Miah1, S S Ahmed, S A Chowdhury
1Department of Dermatology and Venereology, Mymensingh Medical College & Hospital, Mymensingh, Bangladesh.
Mymensingh Medical Journal : MMJ
|December 17, 2008
Summary
Fixed Drug Eruption (FDE) is often caused by cotrimoxazole, with males predominantly affected. This study details FDE clinical presentations and common sites of involvement, particularly on the lips and limbs.
Area of Science:
- Dermatology
- Clinical Pharmacology
- Drug Eruptions
Background:
- Fixed Drug Eruption (FDE) is a specific type of adverse drug reaction.
- Cotrimoxazole is a commonly implicated drug in FDE cases.
- Understanding FDE clinical patterns is crucial for diagnosis and management.
Purpose of the Study:
- To investigate the clinical parameters of Fixed Drug Eruption (FDE).
- To identify specific sites of involvement in FDE.
- To determine the role of cotrimoxazole in causing FDE.
Main Methods:
- Prospective study conducted from January 2003 to December 2006.
- Detailed history, physical examination, and oral re-challenge tests were performed.
- Data collected included age, sex, number of attacks, lesion count, and site distribution.
Main Results:
- Out of 93 suspected FDE cases, 61 were confirmed, with 36 (59.02%) attributed to cotrimoxazole.
- Males were predominantly affected (M:F = 6.2:1), with a mean age of 24.92 years.
- Commonly involved sites included lips (58.33%), limbs (55.56%), and genitalia (33.33%).
Conclusions:
- Cotrimoxazole is a significant cause of Fixed Drug Eruption (FDE).
- FDE presents with characteristic lesion distribution, frequently involving mucocutaneous sites.
- Further research into FDE triggers and prevention is warranted.
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