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Related Experiment Videos

Annular atrophic lichen planus.

D B Friedman1, K Hashimoto

  • 1Department of Dermatology and Syphilogy, Wayne State University School of Medicine, Detroit, MI 48201.

Journal of the American Academy of Dermatology
|August 1, 1991
PubMed
Summary
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This study details a rare case of chronic annular lichen planus, characterized by skin lesions that lose elasticity due to elastic fiber degradation. Inflammatory cells are identified as the cause of this localized acquired cutis laxa.

Area of Science:

  • Dermatology
  • Pathology
  • Histology

Background:

  • Lichen planus is a common inflammatory condition affecting the skin and mucous membranes.
  • Annular lichen planus is a less common morphologic variant, typically presenting as ring-shaped lesions.

Observation:

  • A case of generalized, asymptomatic, chronic annular lichen planus with central atrophy and loss of elasticity in lesions.
  • Histologic examination showed absence of elastic fibers in lesion centers.
  • Electron microscopy revealed fragmented elastic fibers.

Findings:

  • Early lesions demonstrated elastolysis initiated within heavy cellular infiltration.
  • The annular configuration is attributed to elastolytic activity by inflammatory cells.
  • This process leads to the formation of localized acquired cutis laxa.

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Implications:

  • Understanding the mechanism of elastolysis in lichen planus can inform differential diagnoses.
  • This case highlights a specific pathway leading to acquired cutis laxa.
  • Further research into inflammatory cell-mediated elastolysis may reveal new therapeutic targets.