Related Experiment Video
Updated: Jun 28, 2026

05:46
Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
Published on: April 9, 2014
Obstructive uropathy in a HIV+ infant under indinavir treatment
A Serrano-Durbá1, S Vivancos, O Berbel
1Pediatric Urology Unit, Hospital Infantil La Fe, Avenida de Campanar 21, 46009 Valencia, Spain. serrano_agu@gva.es
Journal of Pediatric Urology
|October 25, 2008
Summary
A pediatric case of obstructive uropathy in a 10-year-old HIV-positive male is detailed. The study discusses the condition
Area of Science:
- Pediatric Urology
- Infectious Diseases
- Nephrology
Background:
- Obstructive uropathy can lead to significant renal complications.
- Human Immunodeficiency Virus (HIV) infection presents unique challenges in pediatric care.
- Renoureteral pain is a critical symptom requiring thorough investigation.
Purpose of the Study:
- To present a case of obstructive uropathy in a pediatric HIV patient.
- To discuss the clinical course, diagnosis, and management of this condition.
- To review relevant aspects of epidemiology, treatment, and prevention.
Main Methods:
- Case report presentation.
- Review of clinical findings including renoureteral pain and renal function.
- Description of endoscopic ureteral stent placement.
Main Results:
- A 10-year-old HIV-positive male developed obstructive uropathy.
- Renal function impairment necessitated intervention.
- Successful endoscopic ureteral stent placement was performed.
Conclusions:
- Obstructive uropathy is a serious complication in pediatric HIV patients.
- Prompt diagnosis and intervention are crucial for preserving renal function.
- Management requires a multidisciplinary approach considering the underlying HIV infection.
Related Concept Videos
Pharmacokinetics in Pediatric Patients: Drug Excretion
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Inhibitors of Virion Maturation and Assembly
As part of their replication cycle, certain viruses synthesize long precursor proteins called polyproteins within infected host cells. In human immunodeficiency virus (HIV), two major polyproteins are produced: Gag and Gag-Pol. The Gag polyprotein supplies the structural components of the virus, while Gag-Pol includes essential viral enzymes such as reverse transcriptase, integrase, and protease. After synthesis, these polyproteins move to the host cell membrane, where they assemble into an...
Immunodeficiency Diseases
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
There are three main causes of immunodeficiency disorders...
Cryptococcal Meningitis
Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
Respiratory Syncytial Virus Disease
Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Sexually Transmitted Infections
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...

