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Updated: Jun 28, 2026
10:51
Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
Published on: November 15, 2013
The discovery of equipotent PPARalpha/gamma dual activators
Paul Martres1, Nicolas Faucher, Alain Laroze
1Department of Medicinal Chemistry, Laboratoire GlaxoSmithKline, Centre de Recherches, 25-27 avenue du Québec, 91951 Les Ulis, France. paul.martres@gsk.com
Bioorganic & Medicinal Chemistry Letters
|October 25, 2008
Abstract:
We report the design and synthesis of equipotent PPARalpha/gamma dual agonists starting from selective PPAR alpha agonist 1. In vivo data for 7 in the Zucker fa/fa rat are presented.
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