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A Pacing-Controlled Procedure for the Assessment of Heart Rate-Dependent Diastolic Functions in Murine Heart Failure Models
Published on: July 21, 2023
Heart rate variability in a progressive heart failure model with rapid ventricular pacing
Chiyo Ootaki1, Amy Manzo, Keiji Kamohara
1Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
The Heart Surgery Forum
|October 25, 2008
Summary
Progressive heart failure alters autonomic function, indicated by changes in heart rate variability (HRV) components. Serial HRV measurements can aid in assessing heart failure progression.
Area of Science:
- Cardiology
- Autonomic Neuroscience
- Physiology
Background:
- Heart rate variability (HRV) reflects autonomic nervous system function and predicts cardiac mortality.
- Understanding HRV changes in progressive heart failure is crucial but not fully elucidated.
Purpose of the Study:
- To investigate progressive autonomic system activity changes in a canine model of heart failure.
- To correlate HRV alterations with hemodynamic and echocardiographic parameters during heart failure progression.
Main Methods:
- Heart failure induced via rapid ventricular pacing in mongrel dogs.
- Weekly time and spectral domain analysis of HRV performed.
- Hemodynamic and echocardiographic data collected pre- and post-failure induction.
Main Results:
- Significant decreases in cardiac output and progressive declines in high-frequency HRV components observed.
- Low-frequency HRV components decreased, with an initial increase at 5 weeks.
- The low- to high-frequency ratio varied with heart failure severity.
Conclusions:
- High- and low-frequency HRV components are key indicators for assessing heart failure progression.
- Serial HRV monitoring may offer valuable insights for managing progressive heart failure patients.
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