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Emerging problems of heart failure practice in Japanese women: lessons from the CHART study

Nobuyuki Shiba1, Kotaro Nochioka, Haruka Kohno

  • 1Department of Evidence-based Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan. nshiba@cardio.med.tohoku.ac.jp

Circulation Journal : Official Journal of the Japanese Circulation Society
|October 25, 2008
PubMed

Insights

Female chronic heart failure (CHF) patients are older, have preserved systolic function, and are more likely to have non-ischemic etiology. Further research is needed to understand effective treatment strategies for this demographic.

Area of Science:

  • Cardiology
  • Geriatrics
  • Clinical Research

Background:

  • Chronic heart failure (CHF) affects both men and women, but characteristics and optimal treatments for female patients remain unclear.
  • The Chronic Heart Failure Analysis and Registry in the Tohoku District (CHART-2) cohort provides data to investigate sex-specific differences in CHF.

Purpose of the Study:

  • To evaluate the prognosis and characteristics of female patients within the CHART-2 CHF cohort.
  • To identify factors influencing outcomes in male and female CHF patients.

Main Methods:

  • Analysis of 1,166 symptomatic CHF patients from the CHART-2 registry.
  • Comparison of demographic, clinical, and treatment data between male and female patients.
  • Unadjusted and multivariate survival analyses to identify prognostic factors.

Main Results:

  • Female CHF patients were older, more likely to have preserved systolic function, and non-ischemic etiology compared to males.
  • Female patients showed underuse of standard CHF medications.
  • Unadjusted survival analysis indicated a higher event rate in females, though sex was not a significant prognostic factor in multivariate analysis.
  • Older age, diabetes, ventricular tachycardia, and anemia were significant prognostic risks for both sexes.

Conclusions:

  • Female sex is significantly associated with elderly CHF patients.
  • The increasing elderly population necessitates further research into evidence-based treatments for female CHF patients.
Abstract

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