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Related Concept Videos

Yellow Fever01:18

Yellow Fever

Yellow fever is a viral hemorrhagic disease caused by the yellow fever virus (YFV), a member of the Flaviviridae family. It is transmitted primarily by Aedes and Haemagogus mosquitoes in tropical and subtropical regions of Africa and South America. After transmission through a mosquito bite, the virus initially replicates in skin-resident immune cells such as dendritic cells and macrophages. These cells then migrate to the lymph nodes, where viral replication increases, eventually leading to...
Arboviral Encephalitis01:25

Arboviral Encephalitis

Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
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Rocky Mountain Spotted Fever

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Viral Meningitis01:18

Viral Meningitis

Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
American Trypanosomiasis01:22

American Trypanosomiasis

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Cytomegalovirus Disease

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Updated: Jun 28, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
04:23

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

Case report: vertical dengue infection.

Samara L C Maroun1, Roberta C C Marliere, Rovena C Barcellus

  • 1Instituto Fernandes Figueira, Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, RJ, Brazil.

Jornal De Pediatria
|October 25, 2008
PubMed
Summary
This summary is machine-generated.

Vertical dengue infection occurred in a Brazilian newborn, confirmed by positive IgM antibodies and Dengue type 2 detection. Early pediatrician awareness is crucial for prompt management of this neonatal complication.

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Portable Paper-Based Immunoassay Combined with Smartphone Application for Colorimetric and Quantitative Detection of Dengue NS1 Antigen

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Area of Science:

  • Neonatal infectious diseases
  • Viral transmission
  • Public health in tropical regions

Background:

  • Dengue fever is a significant public health concern, particularly in tropical and subtropical areas.
  • Vertical transmission of dengue, from mother to child, is a recognized but less commonly reported route of infection.
  • Early identification and management are vital for improving neonatal outcomes in dengue-affected regions.

Observation:

  • A case of vertical dengue infection is presented in a neonate from Rio de Janeiro, Brazil.
  • The infant presented with fever and rash on the fifth day of life, with a significant drop in platelet count.
  • Maternal dengue infection occurred three days prior to delivery, with positive IgM antibodies in both mother and infant.

Findings:

  • Polymerase chain reaction confirmed Dengue type 2 in the infected neonate.
  • The infant exhibited thrombocytopenia but no hemorrhagic episodes, including cerebral hemorrhages.
  • Serological testing revealed positive anti-dengue IgM antibodies in both mother and neonate, confirming perinatal transmission.

Implications:

  • This case highlights the importance of considering vertical dengue infection in neonates born to mothers with dengue fever.
  • Pediatricians and neonatologists must be vigilant for symptoms suggestive of dengue in newborns.
  • Timely diagnosis and supportive care are essential for managing vertical dengue infection and preventing severe complications.