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Published on: December 2, 2015
Abnormal electrophysiological activation in schizophrenics during a personal traits attribution task
Jaime R Silva1, Walter M Torres, Manuel S Ortiz
1Departamento de Salud Mental y Psiquiatría, Universidad de La Frontera, Chile.
Schizophrenia may affect early brain responses to self-related information. This study found reduced frontomedial brain activity in individuals with schizophrenia during a self-attribution task, suggesting altered self-referential processing.
Area of Science:
- Neuroscience
- Psychiatry
- Cognitive Science
Background:
- Personal identity changes are a key feature of schizophrenia.
- Medial cortical structures are implicated in self-representation.
Purpose of the Study:
- To investigate differences in frontomedial electrophysiological activation between schizophrenic and normal subjects.
- To examine brain activity during self-attribution tasks.
Main Methods:
- 10 schizophrenic and 7 normal subjects performed a personal traits attribution task (self, other, reading).
- Electroencephalography (EEG) with 128 electrodes recorded brain activity.
- Evoked brain potentials were analyzed in the 180-230 ms time window (P200) over frontomedial electrodes.
Main Results:
- A significant group effect was found in frontomedial electrophysiological activation (p=0.038).
- Schizophrenic subjects showed reduced voltage in the self-attribution condition compared to controls (p=0.033).
Conclusions:
- The findings suggest altered early processing of self-referential information in schizophrenia.
- While not fully supporting the initial hypothesis, results indicate potential impacts on self-referential meaning formation.
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