Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Nucleic Acids and Nucleotides

Nucleic Acids and Nucleotides

Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and have instructions for its functioning. The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA).
Deoxyribonucleic Acid (DNA)
DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and the organelles such as chloroplasts and mitochondria. In...

From DNA to Protein

From DNA to Protein

The flow of genetic information in cells from DNA to mRNA to protein is described by the central dogma, which states that genes specify the sequence of mRNAs, which in turn specify the sequence of amino acids making up all proteins. The decoding of one molecule to another is performed by specific proteins and RNAs. Because the information stored in DNA is so central to cellular function, it makes intuitive sense that the cell would make mRNA copies of this information for protein synthesis...

DNA as a Genetic Template

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...

DNA as a Genetic Template

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...

Labeling DNA Probes

Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...

DNA Base Pairing

DNA Base Pairing

Erwin Chargaff’s rules on DNA equivalence paved the way for the discovery of base pairing in DNA. Chargaff’s rules state that in a double-stranded DNA molecule,

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Outcome measures in rodent models for spinal cord injury and their human correlates.

Experimental neurology·2025

Same author

Behavioral testing in animal models of spinal cord injury.

Experimental neurology·2020

Same author

A simplified method of walking track analysis to assess short-term locomotor recovery after acute spinal cord injury caused by thoracolumbar intervertebral disc extrusion in dogs.

Veterinary journal (London, England : 1997)·2016

Same author

von Frey anesthesiometry to assess sensory impairment after acute spinal cord injury caused by thoracolumbar intervertebral disc extrusion in dogs.

Veterinary journal (London, England : 1997)·2016

Same author

The neuropathological and behavioral consequences of intraspinal microglial/macrophage activation.

Journal of neuropathology and experimental neurology·2002

Same author

Skeletal muscle adaptations following spinal cord contusion injury in rat and the relationship to locomotor function: a time course study.

Journal of neurotrauma·2001

Same journal

Diallel crosses for resistance to Macrophomina phaseolina and Thanatephorus cucumeris on cowpea.

Genetics and molecular research : GMR·2017

Same journal

Diversity among elephant grass genotypes using Bayesian multi-trait model.

Genetics and molecular research : GMR·2017

Same journal

Coupled transcript and metabolite identification: insights on induction and synthesis of resveratrol in peanut, wild relatives and synthetic allotetraploid.

Genetics and molecular research : GMR·2017

Same journal

Estimates of genetics and phenotypics parameters for the yield and quality of soybean seeds.

Genetics and molecular research : GMR·2017

Same journal

In silico modeling and characterization of phytoparasitic nematodes translationally-controlled tumor proteins.

Genetics and molecular research : GMR·2017

Same journal

Molecular identification of variety purity in a cotton hybrid with unknown parentage using DNA-SSR markers.

Genetics and molecular research : GMR·2017

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 28, 2026

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

DNATagger, colors for codons.

N M Scherer¹, D M Basso

¹Bioinformatics Department, Heinrich-Heine-Universität, Düsseldorf, Germany. scherer@cs.uni-duesseldorf.de

Genetics and Molecular Research : GMR

|October 25, 2008

Summary

This summary is machine-generated.

DNATagger is a novel web-based tool that visualizes DNA, RNA, and protein sequences by coloring codons based on amino acids. This unique approach aids in understanding evolutionary processes during sequence analysis.

More Related Videos

Digital PCR-based Competitive Index for High-throughput Analysis of Fitness in Salmonella

Digital PCR-based Competitive Index for High-throughput Analysis of Fitness in Salmonella

Published on: May 13, 2019

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

Related Experiment Videos

Last Updated: Jun 28, 2026

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

Digital PCR-based Competitive Index for High-throughput Analysis of Fitness in Salmonella

Digital PCR-based Competitive Index for High-throughput Analysis of Fitness in Salmonella

Published on: May 13, 2019

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

Area of Science:

Bioinformatics
Computational Biology
Molecular Biology

Background:

Sequence analysis is crucial for understanding biological processes.
Visualizing DNA, RNA, and protein sequences aids in comprehending evolutionary relationships.
Existing tools may have limitations in handling sequence alignments and codon visualization.

Purpose of the Study:

To introduce DNATagger, a web-based tool for enhanced visualization and editing of biological sequences.
To facilitate the comprehension of evolutionary processes through codon-based coloring of DNA and RNA sequences.
To provide a user-friendly, platform-independent solution for sequence analysis.

Main Methods:

DNATagger utilizes codons as the fundamental units for coloring DNA and RNA sequences.
Amino acids determine the color of each codon, providing an informative visualization.
The tool is implemented as a JavaScript application, adhering to W3C guidelines for broad browser compatibility.
It handles single and in-frame gaps within alignments without affecting codon coloring.

Main Results:

DNATagger offers a unique method for coloring DNA/RNA sequences based on codons and their corresponding amino acids.
It is the first program capable of coloring codons accurately, irrespective of 'out-of-frame' gaps in alignments.
The tool allows for alignment editing, customizable color schemes, and the use of different translation tables.
Being a web-based JavaScript application, DNATagger requires no installation and is compatible with all major web browsers.

Conclusions:

DNATagger provides an innovative and effective approach to visualizing and analyzing biological sequences.
Its codon-based coloring and gap-handling capabilities enhance the study of evolutionary processes.
The tool's accessibility as free, open-source, and platform-independent software promotes its widespread adoption in bioinformatics.