Cerebrospinal fluid angiogenin level in patients with amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease. It is suggested that angiogenin (ANG) may play a role in the pathomechanism of this disease. The aim of the study was to measure cerebrospinal fluid (CSF) ANG levels in patients with ALS. Twenty ALS patients and 15 control subjects were included in the study. CSF ANG levels were measured by ELISA. Study results showed that CSF ANG level did not differ between ALS patients and control group (p > 0.05). There was no significant correlation between CSF ANG level and clinical state of ALS patients either (p > 0.05). The present study conducted on CSF of patients with ALS did not confirm previous observation on the possible role of ANG in neurodegeneration in this disease.