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Updated: Jun 28, 2026
Regenerative Therapy by Suprachoroidal Cell Autograft in Dry Age-related Macular Degeneration: Preliminary In Vivo Report
Published on: February 12, 2018
[Photodynamic therapy in age-related macular degeneration: one-year results]
Kasumi Ohira-Tochigi1, Eisei Yokoyama, Yoko Matsumoto
1Division of Ophthalmology, Department of Visual Science, Nihon University School of Medicine, Japan. tkasuminn@yahoo.co.jp
Purpose:
To evaluate the efficacy of photodynamic therapy (PDT) for subfoveal choroidal neovascularization(CNV) secondary to age-related macular degeneration(AMD) one year after PDT.
Patients And Methods:
106 eyes of 106 AMD patients with subfoveal CNV detected by fluorescein angiography (FA). Best-corrected visual acuity, color fundus photography, FA and indocyanine green angiography were performed before and 1 year after treatment. Visual acuity and CNV size before PDT were compared with those 1 year after treatment. Pre-PDT factors predicting a visual acuity of 0.4 or more 1 year after this treatment were evaluated.
Results:
Visual acuity improved or was maintained in 84 of the 106 eyes. The size of CNV decreased significantly (p < 0.001). A visual acuity of 0.4 or more 1 year after PDT was predicted by an acuity of 0.4 or more (p = 0.01) and occult with no classic CNV (p = 0.04) prior to PDT.
Conclusions:
PDT is effective for maintaining or improving visual acuity and obliteration of CNV for 1 year or longer. Factors predicting a visual acuity of 0.4 or more 1 year after PDT were an acuity of 0.4 or more and occult with no classic CNV prior to PDT.
