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Generation of Murine Cardiac Pacemaker Cell Aggregates Based on ES-Cell-Programming in Combination with Myh6-Promoter-Selection

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Clear cell hidradenocarcinoma developing in pacemaker pocket.

Cesar V Reyes¹

¹Department of Clinical Laboratories, Morris Hospital and Hines VA Hospital, Morris, Illinois, USA. creyes@morrishospital.org

Pacing and Clinical Electrophysiology : PACE

|October 28, 2008

Summary

A rare sweat gland cancer, clear cell hidradenocarcinoma, developed in an elderly woman after pacemaker implantation. Post-surgical evaluation confirmed no other malignancy, indicating a unique cancer origin.

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Area of Science:

Oncology
Dermatopathology
Surgical Pathology

Background:

Clear cell hidradenocarcinoma is a rare malignant neoplasm originating from eccrine sweat glands.
The case involves an elderly female patient with a history of pacemaker implantation.

Observation:

The patient presented with a clear cell hidradenocarcinoma in the right lateral chest, near the pacemaker site.
Immunohistochemical analysis revealed the tumor mimicked metastatic lobular breast carcinoma (positive estrogen, progesterone, mammoglobin).

Findings:

Surgical excision and axillary lymph node dissection were performed.
The patient refused recommended irradiation.
Postmortem evaluation, mammograms, and follow-up confirmed no primary breast cancer or other metastatic disease.

Implications:

This case highlights a rare instance of clear cell hidradenocarcinoma potentially linked to pacemaker implantation.
The tumor's immunohistochemical profile presented a diagnostic challenge, mimicking breast carcinoma.
The findings underscore the importance of considering rare sweat gland tumors in differential diagnoses, even with seemingly common immunohistochemical markers.