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Laboratory testing for fibrinogen abnormalities

Madeleine Verhovsek1, Karen A Moffat, Catherine P M Hayward

  • 1Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.

American Journal of Hematology
|October 28, 2008
PubMed

Fibrinogen is essential for the formation of a fibrin clot. Acquired and congenital disorders of fibrinogen may result in decreased concentration or altered function of fibrinogen, often leading to an increased risk of bleeding. Routine coagulation testing and specialized laboratory investigations can guide diagnosis in patients suspected of having a fibrinogen abnormality. This article summarizes the types of laboratory assays that are used to assess fibrinogen disorders, and key abnormalities found in different types of fibrinogen disorders.

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