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Preparation of Murine Submandibular Salivary Gland for Upright Intravital Microscopy

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Published on: May 7, 2018

Submandibular space infection: a potentially lethal infection.

Paolo Boscolo-Rizzo¹, Maria Cristina Da Mosto

¹Department of Medical and Surgical Specialities, Otolaryngology Clinic - Regional Center for Head and Neck Cancer, University of Padua, School of Medicine, Treviso Regional Hospital, Treviso, Italy. paolo.boscolorizzo@unipd.it

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases

|October 28, 2008

Summary

Submandibular space infections can lead to life-threatening complications. Anterior visceral space involvement and diabetes mellitus are key risk factors, requiring vigilant clinical assessment and early intervention, including surgical drainage when necessary.

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Cannulation of the Mouse Submandibular Salivary Gland via the Wharton's Duct

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Published on: May 14, 2011

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Last Updated: Jun 28, 2026

Preparation of Murine Submandibular Salivary Gland for Upright Intravital Microscopy

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Published on: May 7, 2018

Cannulation of the Mouse Submandibular Salivary Gland via the Wharton's Duct

Cannulation of the Mouse Submandibular Salivary Gland via the Wharton's Duct

Published on: May 14, 2011

Area of Science:

Otolaryngology
Infectious Diseases
Surgical Pathology

Background:

Submandibular space infections are serious conditions with potential for severe complications.
Identifying predisposing factors is crucial for timely and effective management.

Purpose of the Study:

To review clinical characteristics and management of submandibular space infections.
To identify predisposing factors for life-threatening complications.

Main Methods:

Retrospective study at a tertiary academic center (1998-2006).
Analysis of patient records including demographics, pathogenesis, clinical presentation, comorbidities, bacteriology, imaging, treatment, and complications.
Multivariate logistic regression analysis to identify risk factors.

Main Results:

Anterior visceral space involvement (OR 54.44) and diabetes mellitus (OR 17.46) were significant predictors of complications.
Other comorbidities (OR 11.66) and bilateral submandibular swelling (OR 10.67) were also independent predictors.
Four key risk factors for life-threatening complications were identified.

Conclusions:

Airway obstruction and mediastinal spread are critical complications.
Management strategies vary from antibiotics alone for small infections to surgical drainage for larger abscesses or specific risk factors.
Patients with comorbidities, particularly diabetes mellitus, require heightened suspicion for complications and consideration for early surgical intervention.