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Published on: August 29, 2012

Targeting minor histocompatibility antigens in graft versus tumor or graft versus leukemia responses

Xin Feng1, Kwok Min Hui, Hashem M Younes

  • 1Department of Medicine, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA.

Trends in Immunology
|October 28, 2008
PubMed

Allogeneic hematopoietic cell transplantation (alloHCT) represents the only curative therapy for several hematologic malignancies, and shows promise as a nascent treatment modality for select solid tumors. Although the original goal of alloHCT was hematopoietic reconstitution after sub-lethal chemoradiotherapy, recognition of a profound donor lymphocyte-mediated graft-versus-leukemia (GVL) or graft-versus-tumor (GVT) effect has shifted the paradigm from pre-transplant cytoreduction to tumor control via donor lymphocytes. In human leukocyte antigen (HLA)-compatible alloHCT, GVL and GVT reactions are induced primarily by donor T-cell recognition of minor histocompatibility antigens (mHAgs). Here we review the literature regarding mHAg-specific T cells in GVL and GVT reactions, and discuss the prospects of exploiting mHAgs as immunotherapeutic targets.

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