Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
Inborn Errors of Metabolism01:20

Inborn Errors of Metabolism

Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
Other Pulmonary Disorders01:17

Other Pulmonary Disorders

Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

250 cases of "type 2 Gaucher disease": A novel system of clinical categorisation and evidence of genotype: Phenotype correlation.

Molecular genetics and metabolism·2025
Same author

Henoch-Schönlein purpura nephritis and IgA nephropathy: a comparative clinical study.

Clinical and experimental rheumatology·2013
Same author

[PANDAS with a chorea-like clinical presentation and associated autoimmune pathology: a case report].

Revista de neurologia·2009
Same author

[Rare diseases: medicine's challenge in the XXI Century].

Anales del sistema sanitario de Navarra·2008
Same author

[Genetically based diseases].

Anales del sistema sanitario de Navarra·2008
Same author

[Needs in rare diseases during paediatric age].

Anales del sistema sanitario de Navarra·2008
Same journal

[Subacute meningoencephalitis following intravesical BCG instillation immunotherapy].

Anales del sistema sanitario de Navarra·2026
Same journal

[Treatment with dabrafenib and trametinib in an intrahepatic cholangiocarcinoma harboring a BRAF V600E mutation].

Anales del sistema sanitario de Navarra·2026
Same journal

[Efficiency after integrating a hospital with a 'new management model'].

Anales del sistema sanitario de Navarra·2026
Same journal

[Anales del Sistema Sanitario de Navarra in 2025: Progress continues].

Anales del sistema sanitario de Navarra·2026
Same journal

Qualitative evaluation of a community intervention in educational centres: Opinion of the professionals involved.

Anales del sistema sanitario de Navarra·2026
Same journal

[Unequal impact of COVID-19 on mortality in long-term care homes across health areas of Castilla-La Mancha (Spain)].

Anales del sistema sanitario de Navarra·2026
See all related articles

Related Experiment Video

Updated: Jun 28, 2026

Robot-Assisted Laparoscopic Splenectomy In Children: A Case Report with Literature Review
05:06

Robot-Assisted Laparoscopic Splenectomy In Children: A Case Report with Literature Review

Published on: March 27, 2026

[Rare diseases in paediatrics].

D González-Lamuño1, M García Fuentes

  • 1Seccion de Peiatria, Universidad de Cantabria-Hospital Universitario Marqués de Valdecilla, Santander, 39011, Spain. pedgld@humv.es

Anales Del Sistema Sanitario De Navarra
|November 26, 2008
PubMed
Summary
This summary is machine-generated.

Caring for children with rare diseases (RDs) and their families requires specialized pediatric training. Continuous monitoring and comprehensive care are essential to minimize handicaps and support families facing lifelong challenges.

Related Experiment Videos

Last Updated: Jun 28, 2026

Robot-Assisted Laparoscopic Splenectomy In Children: A Case Report with Literature Review
05:06

Robot-Assisted Laparoscopic Splenectomy In Children: A Case Report with Literature Review

Published on: March 27, 2026

Area of Science:

  • Pediatric rare disease management
  • Family-centered care in rare diseases

Context:

  • Rare diseases (RDs) present unique challenges in pediatric care, often involving malformations and lifelong impacts.
  • Families of children with RDs require significant support in decision-making and adaptation.

Purpose:

  • To highlight the critical need for specialized pediatric training in managing rare diseases.
  • To emphasize the importance of continuous monitoring and comprehensive care for children with RDs and their families.

Summary:

  • Pediatric rare disease care demands specialized knowledge and continuous monitoring for both the child's condition and family adaptation.
  • Effective management involves addressing the multifaceted challenges, including malformations and lifelong impacts, to minimize potential handicaps.

Impact:

  • Enhanced pediatric training in rare diseases can improve diagnostic and monitoring capabilities.
  • Integrated care approaches are vital for minimizing the long-term impact of rare diseases on children and their families.