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[PANDAS with a chorea-like clinical presentation and associated autoimmune pathology: a case report]
S Otero-Cuesta1, O Fernández-Torre, D González-Lamuño
1Unidad de Psiquiatría y Psicología Infanto-Juvenil (UPPIJ), Servicio de Psiquiatría, Servicio de Pediatría, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, Spain. sotero@humv.es
Introduction:
The disorder known as 'PANDAS syndrome' (paediatric autoimmune neuro-psychiatric disorders associated with Streptococci) consists in an abrupt onset of obsessive-compulsive symptoms and/or movement disorders, a pre-puberal onset, and an episodic course. Antibiotic therapy has been postulated as a first choice therapeutic option. A summarised review of main literature on this topic is presented.
Case Report:
A girl, 10 years and 6 months old, with a dramatic clinical onset of a chorea-like and obsessive-compulsive symptomathology with a remarkable improvement after 10 days penicillin p.o. intake. She has a positive family history of autoimmune disorders, with elevated anti-phospholipidic antibodies.
Conclusion:
The implications of the case follow-up with many relapses, the development of a diabetes after corticoid therapy and the elevated anti glutamic dexcarboxilasa (anti-GAD) are discussed regarding a common underlying autoimmune mechanism.
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