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An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
Published on: December 10, 2013
Immunity to respiratory viruses
Jacob E Kohlmeier1, David L Woodland
1Trudeau Institute, Saranac Lake, New York 12983, USA.
Annual Review of Immunology
|October 29, 2008
Summary
Pulmonary immune responses to respiratory viruses involve complex innate and adaptive mechanisms. Understanding these processes is crucial for effective antiviral immunity and host defense against secondary infections.
Area of Science:
- Immunology
- Respiratory Medicine
- Virology
Background:
- The respiratory tract's large surface area presents challenges for immune surveillance.
- Innate and adaptive immune systems coordinate to control most respiratory pathogens.
Purpose of the Study:
- To review recent advances in understanding pulmonary immunity to respiratory viruses.
- To elucidate the roles of immune components in primary and secondary viral infections of the lung.
Main Methods:
- Review of current literature on pulmonary antiviral immunity.
- Analysis of studies investigating primary and recall immune responses in the lung.
Main Results:
- Multiple innate and adaptive immune mechanisms are essential for effective antiviral responses.
- Inhibition of single immune mechanisms can lead to severe host consequences.
- Secondary protection involves a complex, multi-stage recall response.
Conclusions:
- Recent discoveries enhance our understanding of antiviral immunity in the lung.
- Knowledge of primary and secondary responses is critical for combating respiratory viral infections.
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