Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Glaucoma: Overview

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

GWAS meta-analysis provides new insights into uveal melanoma risk.

British journal of cancer·2026

Same author

Novel CRISPR-Cas9 BAP1 knockout pre-clinical tumor model recapitulates human melanoma tumorigenesis and immune evolution.

Communications biology·2026

Same author

Lenalidomide-rituximab or lenalidomide-rituximab-bendamustine for relapsed/refractory follicular lymphoma: primary and final analysis of the randomized phase II HOVON110/ReBeL study.

Haematologica·2026

Same author

Tissue resident memory T cells populate the human uveal tract.

Scientific reports·2026

Same author

The complement system contributes to the immunosuppressive microenvironment of uveal melanoma.

Journal of translational medicine·2026

Same author

Validation of MOLES score for small choroidal melanomas: impact of assuming enlargement for telemedicine in sizable lesions.

Eye (London, England)·2026

Same journal

Biopsy of Iris and Anterior Chamber Tumours: Fine Needle, Minimally Invasive and Excision Techniques - Review.

Clinical & experimental ophthalmology·2026

Same journal

Ray-Tracing-Based Intraocular Lens Power Calculation in Combined Cataract Surgery and Descemet Membrane Endothelial Keratoplasty.

Clinical & experimental ophthalmology·2026

Same journal

Comparative Efficacy of Two Defocus Soft Contact Lenses on Axial Length and Choroid in High Myopic Adolescents: Comment.

Clinical & experimental ophthalmology·2026

Same journal

Lessons Learnt From 25 Years of Endophthalmitis: Causes, Microbiology and Visual Outcome Trends.

Clinical & experimental ophthalmology·2026

Same journal

Aqueous Humour Outflow Assessment Using Imaging-Based Techniques in Angle-Based Minimally Invasive Glaucoma Surgery (MIGS): A Systematic Review.

Clinical & experimental ophthalmology·2026

Same journal

Interpreting Hyperreflective Foci in Age-Related Macular Degeneration: A Critical Review of Cell Origins, Evolving Terminology and Clinical Utility.

Clinical & experimental ophthalmology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 28, 2026

Cell-Free DNA Extraction of Vitreous and Aqueous Humor Specimens for Diagnosis and Monitoring of Vitreoretinal Lymphoma

Cell-Free DNA Extraction of Vitreous and Aqueous Humor Specimens for Diagnosis and Monitoring of Vitreoretinal Lymphoma

Published on: January 12, 2024

Understanding intraocular lymphomas.

Sarah E Coupland¹, Bertil Damato

¹Department of Cellular and Molecular Pathology, University of Liverpool, Liverpool, UK. s.e.coupland@liverpool.ac.uk

Clinical & Experimental Ophthalmology

|October 29, 2008

Summary

This summary is machine-generated.

Intraocular lymphomas are diverse malignant neoplasms. Classifying them by location (retina, uvea) and type (primary/secondary) improves understanding of their distinct clinical features and origins.

More Related Videos

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Published on: December 2, 2022

Intravital Imaging of Intraepithelial Lymphocytes in Murine Small Intestine

Intravital Imaging of Intraepithelial Lymphocytes in Murine Small Intestine

Published on: June 24, 2019

Related Experiment Videos

Last Updated: Jun 28, 2026

Cell-Free DNA Extraction of Vitreous and Aqueous Humor Specimens for Diagnosis and Monitoring of Vitreoretinal Lymphoma

Cell-Free DNA Extraction of Vitreous and Aqueous Humor Specimens for Diagnosis and Monitoring of Vitreoretinal Lymphoma

Published on: January 12, 2024

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Published on: December 2, 2022

Intravital Imaging of Intraepithelial Lymphocytes in Murine Small Intestine

Intravital Imaging of Intraepithelial Lymphocytes in Murine Small Intestine

Published on: June 24, 2019

Area of Science:

Ophthalmology
Hematology
Oncology

Background:

Intraocular lymphomas are a heterogeneous group of malignant neoplasms affecting the eye.
Existing terminology like 'primary intraocular lymphoma' (PIOL) is imprecise.
Understanding the specific characteristics of lymphomas in different ocular compartments is crucial.

Purpose of the Study:

To review the clinical features, pathology, and molecular biology of intraocular lymphomas.
To propose an anatomical classification based on ocular location (retina vs. uvea).
To overview diagnostic investigations and biopsy considerations.

Main Methods:

Review of existing literature on intraocular lymphomas.
Analysis of clinical, pathological, and molecular data.
Comparative analysis of lymphomas based on ocular site.

Main Results:

Retinal lymphomas are aggressive, high-grade B-cell malignancies with poor prognosis, often linked to central nervous system disease.
Primary choroidal lymphomas are typically indolent, low-grade B-cell tumors resembling extranodal marginal zone B-cell lymphomas (EMZL).
Primary iridal lymphomas are rare, with mixed B- and T-cell types and a variable course, often leading to systemic dissemination.

Conclusions:

A precise classification of intraocular lymphomas should specify location (retinal, choroidal, iridal, ciliary) and status (primary or secondary).
Retinal and choroidal lymphomas originate from post-germinal center B cells.
Secondary uveal lymphomas occur in patients with established systemic lymphoma or leukemia.