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Updated: Jun 28, 2026
06:31
Identification and Dissection of Diverse Mouse Adipose Depots
Published on: July 11, 2019
Dual role of complement in adipose tissue.
Michael Pattrick1, Jeni Luckett, Liang Yue
1Dept. of Infection, Immunity and Inflammation, University of Leicester, University Road, Leicester LE 1 9HN, United Kingdom.
Molecular Immunology
|October 29, 2008
Summary
Adipose tissue, once viewed solely for energy storage, is now recognized for its metabolic and endocrine functions. This review explores its role in producing complement, highlighting its immunological significance in systemic inflammation.
Area of Science:
- Immunology
- Endocrinology
- Metabolic research
Background:
- Adipose tissue is increasingly recognized for its metabolic and endocrine roles beyond energy storage.
- Complement system production is traditionally attributed to hepatic synthesis and macrophages.
- Early research suggested adipocytes might also synthesize complement components.
Purpose of the Study:
- To re-examine the historical evidence for adipocyte synthesis of complement components.
- To emphasize the immunological activity of adipose tissue.
- To advocate for a comprehensive analysis of adipose tissue's contribution to systemic inflammation.
Main Methods:
- Literature review of early descriptions of adipocyte complement synthesis.
- Analysis of existing data on adipose tissue and immune function.
Main Results:
- Adipocytes have been historically described as capable of synthesizing complement components.
- The extent of adipose tissue contribution to systemic complement levels requires further investigation.
Conclusions:
- Adipose tissue possesses significant immunological activity.
- Systematic analysis of adipose tissue's role in complement production is crucial for understanding its contribution to inflammation.
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