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[Age-related changes in the kidney of patients with mild mesangial proliferative glomerulonephritis]
Abstract:
In order to clarify age-related changes in kidneys, the renal function and histological changes were evaluated in 962 patients with mild mesangial proliferative glomerulonephritis (Mes PGN) whose ages ranged from 7 to 82 years. The glomerular filtration rate (GFR) (Ccr), renal plasma flow (RPF) (CPAH) and PSP excretion rate were significantly lower in nephritic patients than in normal subjects. Age-related decreases of GFR, RPF, PSP excretion rate and maximal urine specific gravity in Fishberg concentration test were found in both groups. Serum levels of creatinine, urea nitrogen and uric acid were significantly higher in nephritic patients than in the normal population. Age-related increases of those parameters were found in both groups. The incidence of sclerotic glomeruli was almost same as that of the normal population estimated by Kaplan et al. The incidence of arterio- and arteriolosclerosis was also higher than that of normal subjects estimated by Bell. Thus, arterio- and arteriolosclerosis seems to be more age-dependent than glomerulosclerosis in patients with mild Mes PGN. In conclusion, renal functions decrease and renal arteriolar lesions increase gradually in proportion to aging. Mes PGN, even mild, can accelerate the physiological age-related decrease of renal function.
Insights
Mild mesangial proliferative glomerulonephritis (Mes PGN) accelerates age-related kidney function decline. Patients with Mes PGN show reduced renal function and increased arteriolar lesions compared to healthy individuals.
Area of Science:
- Nephrology
- Gerontology
- Pathology
Context:
- Age-related kidney changes are a significant concern in public health.
- Understanding the impact of chronic kidney conditions on aging is crucial.
Purpose:
- To investigate age-related renal functional and histological changes in patients with mild mesangial proliferative glomerulonephritis (Mes PGN).
- To compare renal parameters in Mes PGN patients with normal subjects across a wide age range.
Summary:
- Evaluated 962 patients (ages 7-82) with mild Mes PGN, assessing glomerular filtration rate (GFR), renal plasma flow (RPF), PSP excretion, and serum markers.
- Found significantly lower GFR, RPF, and PSP excretion, with higher serum creatinine, urea nitrogen, and uric acid in Mes PGN patients versus controls.
- Observed age-related declines in renal function and increases in serum markers in both groups. Arterio- and arteriolosclerosis were more prevalent and age-dependent in Mes PGN patients than glomerulosclerosis.
Impact:
- Mild Mes PGN accelerates the natural age-related decline in kidney function.
- Renal arteriolar lesions increase with age, suggesting a heightened susceptibility in Mes PGN patients.
- Findings highlight the importance of managing Mes PGN to preserve renal health in aging populations.