Related Experiment Video
Updated: Jun 28, 2026

06:11
Anterior Cervical Discectomy and Fusion in the Ovine Model
Published on: October 5, 2009
Fusion versus Bryan Cervical Disc in two-level cervical disc disease: a prospective, randomised study
1Orthopaedic and Trauma Department, Qilu Hospital of Shandong University, No. 107 Wenhua Xi Road, Jinan, Shandong, 250012, People's Republic of China. chengleiyx@126.com
International Orthopaedics
|October 29, 2008
Summary
Bryan Cervical Disc replacement offers comparable functional results to fusion for two-level cervical disc disease. This artificial disc replacement shows reliability and safety in treating this condition.
Area of Science:
- Neurosurgery
- Orthopedic Surgery
- Spinal Surgery
Background:
- Two-level cervical disc disease presents a significant clinical challenge.
- Surgical options include anterior cervical fusion and artificial disc replacement.
- Comparing outcomes is crucial for treatment selection.
Purpose of the Study:
- To compare functional and radiographic outcomes of Bryan Cervical Disc replacement versus anterior cervical fusion.
- To evaluate the efficacy of artificial disc replacement for two-level cervical disc disease.
Main Methods:
- Prospective randomized study of 65 patients with two-level cervical disc disease.
- Patients randomly assigned to Bryan Cervical Disc replacement (31) or anterior cervical fusion (34).
- Clinical assessment using VAS, SF-36, and NDI; radiographic assessment of range of motion, stability, and subsidence over two years.
Main Results:
- Both groups showed substantial reduction in Neck Disability Index (NDI) scores.
- The Bryan Cervical Disc replacement group demonstrated a greater percent improvement in NDI (P = 0.023).
- Significant improvement in arm pain Visual Analogue Scale (VAS) scores was observed in both groups.
Conclusions:
- Bryan artificial cervical disc replacement is a reliable and safe option for two-level cervical disc disease.
- Artificial disc replacement may offer superior functional recovery compared to fusion in specific patient populations.
- Further research can explore long-term outcomes and patient-specific indications.
Related Concept Videos
Herniated Intervertebral Disc l: Introduction
Intervertebral disc herniation refers to the displacement of the nucleus pulposus (the gel-like inner core of the disc) through a tear or weakened area in the annulus fibrosus (the outer fibrous ring). The displaced disc material extends beyond the normal boundaries of the disc space and may compress or irritate nearby spinal nerve roots or, less commonly, the spinal cord.Etiology and Risk FactorsHerniation commonly results from degeneration, in which aging reduces disc hydration and...
Degenerative Disc Disease I: Introduction
Degenerative disc disease is a chronic condition in which intervertebral discs gradually lose structure and function. It is not infectious or autoimmune; rather, it results from age-related biochemical and mechanical changes, influenced by genetic, metabolic, and environmental factors.Structure and Function of DiscsThe spine contains 23 intervertebral discs that absorb load, distribute forces, maintain spacing, and allow flexibility. Each disc consists of a nucleus pulposus, a gel-like core...
Degenerative Disc Disease ll: Pathophysiology
The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...