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Related Concept Videos

Abdominal Aorta01:25

Abdominal Aorta

Once the aorta traverses the diaphragmatic plane at the aortic hiatus, it is known as the abdominal aorta. This anatomical structure is positioned leftward of the spinal column, encased within a cocoon of adipose tissue behind the peritoneal cavity. It terminates at the L4 vertebra, where it splits into the common iliac arteries. Prior to this bifurcation, the abdominal aorta gives rise to several vital branches.
The celiac trunk, a singular artery, divides into the left gastric artery, which...
Aneurysm I: Introduction01:30

Aneurysm I: Introduction

An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
Thoracic Aorta01:15

Thoracic Aorta

The thoracic section of the aorta begins at the T5 vertebra and extends to the T12 level at the diaphragm, initially progressing through the mediastinum to the left of the spinal column. Throughout its course in the thoracic segment, the thoracic aorta emits various offshoots known collectively as visceral and parietal branches. The branches that predominantly supply blood to visceral organs are termed visceral branches and include bronchial, pericardial, esophageal, and mediastinal arteries,...

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Related Experiment Video

Updated: Jun 28, 2026

Ultrasound Imaging of the Thoracic and Abdominal Aorta in Mice to Determine Aneurysm Dimensions
06:08

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Published on: March 8, 2019

[Gene expression difference analysis between abdominal aorta aneurysm and normal abdominal artery].

Hai-Guang Zhao1, Shi-Jun Fu, Mi-Er Jiang

  • 1Department of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200011, China.

Zhonghua Wai Ke Za Zhi [Chinese Journal of Surgery]
|October 30, 2008
PubMed
Summary

Gene expression analysis revealed significant differences in abdominal aorta aneurysm (AAA) compared to normal arteries. Key immune and inflammatory genes were notably altered in AAA, offering insights into its development.

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Area of Science:

  • Molecular Biology
  • Genomics
  • Vascular Biology

Context:

  • Abdominal aorta aneurysm (AAA) is a life-threatening condition characterized by the dilation of the abdominal aorta.
  • Understanding the molecular mechanisms underlying AAA pathogenesis is crucial for developing effective treatments.
  • Gene expression profiling provides a powerful tool to identify molecular signatures associated with diseases.

Purpose:

  • To identify and characterize gene expression differences between human abdominal aorta aneurysm (AAA) and normal abdominal artery tissues.
  • To elucidate the molecular pathways and biological processes implicated in AAA development through differential gene expression analysis.

Summary:

  • Gene expression profiling was performed on five AAA and five normal abdominal artery specimens using Affymetrix Genechips.
  • A total of 1,962 differentially expressed genes were identified, with 554 genes upregulated and 1,408 genes downregulated in AAA.
  • Functional analysis highlighted significant upregulation of genes associated with immune response, inflammatory response, and chemokines in AAA.

Impact:

  • The identified differentially expressed genes provide potential molecular markers for AAA.
  • These findings contribute to a deeper understanding of the complex biological mechanisms driving AAA pathogenesis.
  • This research may pave the way for novel diagnostic and therapeutic strategies targeting AAA.