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Updated: Jun 28, 2026
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Multi-system Monitoring for Identification of Seizures, Arrhythmias and Apnea in Conscious Restrained Rabbits
Published on: March 27, 2021
Aripiprazole-induced rabbit syndrome: a case report
A Caykoylu1, O Ekinci, M Kuloglu
1Department of Psychiatry, Atatürk Education and Research Hospital, Ankara, Turkey.
Journal of Psychopharmacology (Oxford, England)
|October 30, 2008
Summary
Rabbit syndrome (RS), a rare neuroleptic side effect, can occur with atypical antipsychotics like aripiprazole. This case highlights the need for caution, even with newer medications known for fewer motor side effects.
Area of Science:
- Neuroscience
- Pharmacology
Background:
- Rabbit syndrome (RS) is a rare neuroleptic-induced side effect characterized by vertical rhythmic oral movements.
- While associated with older antipsychotics, its risk with newer atypical agents remains less understood.
Observation:
- Aripiprazole, an atypical antipsychotic, is generally associated with a lower risk of extrapyramidal side effects.
- This report details a case of RS developing in a patient treated with aripiprazole.
Findings:
- The case suggests that aripiprazole, despite its favorable side effect profile, can still precipitate Rabbit syndrome.
- Potential mechanisms involving dopamine D2 receptor occupancy and dopamine hypersensitivity are discussed.
Implications:
- This case underscores the importance of vigilance for extrapyramidal side effects, including RS, even when prescribing newer antipsychotics like aripiprazole.
- Further research may be needed to fully elucidate the risk factors and mechanisms of RS with atypical antipsychotics.
