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Related Concept Videos

Interpreting ¹H NMR Signal Splitting: The (n + 1) Rule01:10

Interpreting ¹H NMR Signal Splitting: The (n + 1) Rule

In the AX proton spin system, proton A can sense the two spin states of a coupled proton X, resulting in a doublet NMR signal with two peaks of equal (1:1) intensity. When proton A is coupled to two equivalent protons (AX2 spin system), the spin states of each X can be aligned with or against the external field, creating three possible scenarios. This results in a 1:2:1  triplet signal, where the central peak corresponds to the chemical shift of A and is twice as large or intense as the others.
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Catenins01:23

Catenins

Catenins are characterized by multiple binding domains and dynamic structures that allow them to function as linker proteins in cell junction complexes. All catenins, except α-catenin, contain a characteristic protein sequence called the armadillo repeat and are therefore also called armadillo proteins.
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Allosteric Proteins-ATCase01:19

Allosteric Proteins-ATCase

Binding sites linkages can regulate a protein's function.  For example, enzyme activity is often regulated through a feedback mechanism where the end product of the biochemical process serves as an inhibitor.
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C4 Pathway and CAM

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Related Experiment Video

Updated: Jun 28, 2026

Expression Analysis of Mammalian Linker-histone Subtypes
14:40

Expression Analysis of Mammalian Linker-histone Subtypes

Published on: March 19, 2012

The HIF-1 alpha-C/EBP alpha axis.

Harish P Janardhan1

  • 1Department of Biochemistry, Christian Medical College, Vellore, India. harishpj@cmcvellore.ac.in

Science Signaling
|October 30, 2008
PubMed
Summary
This summary is machine-generated.

Hypoxia inducible factors (HIFs) and CCAAT/enhancer binding protein alpha (C/EBP alpha) interact, altering each other's activity. This interaction influences cellular responses to low oxygen and energy metabolism in a tissue-specific manner.

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Last Updated: Jun 28, 2026

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Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions
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Promoter Capture Hi-C: High-resolution, Genome-wide Profiling of Promoter Interactions

Published on: June 28, 2018

Area of Science:

  • Cellular Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Hypoxia inducible factors (HIFs) regulate cellular adaptation to low oxygen environments.
  • CCAAT/enhancer binding protein alpha (C/EBP alpha) plays a key role in energy metabolism and cell differentiation.
  • Emerging evidence points to a functional interplay between HIFs and C/EBP alpha.

Purpose of the Study:

  • To explore the interaction between HIF-1 alpha and C/EBP alpha.
  • To discuss the reciprocal functional changes induced by this interaction.
  • To identify conditions and tissues where this interaction is relevant.

Main Methods:

  • Literature review of existing research on HIF-1 alpha and C/EBP alpha interactions.
  • Analysis of studies investigating the functional consequences of these interactions.
  • Discussion of experimental evidence supporting the interplay.

Main Results:

  • HIF-1 alpha and C/EBP alpha interactions lead to decreased HIF-1 alpha activity.
  • C/EBP alpha activity is modulated (restricted or increased) in a tissue-specific manner upon interaction.
  • The interaction impacts cellular adaptive responses and energy metabolism.

Conclusions:

  • The interaction between HIF-1 alpha and C/EBP alpha represents a novel regulatory mechanism.
  • Understanding this interplay is crucial for comprehending cellular responses in various physiological and pathological conditions.
  • Further research is warranted to fully elucidate the scope and implications of this interaction across different tissues.