The HIF-1 alpha-C/EBP alpha axis
Related Experiment Video
Updated: Jun 28, 2026

Expression Analysis of Mammalian Linker-histone Subtypes
Published on: March 19, 2012
1Department of Biochemistry, Christian Medical College, Vellore, India. harishpj@cmcvellore.ac.in
Abstract:
The hypoxia inducible factors (HIFs) and CCAAT/enhancer binding protein alpha (C/EBP alpha) are transcription factors that mediate adaptive responses to hypoxia and control aspects of energy metabolism, respectively. New evidence suggests that when HIF-1 alpha and C/EBP alpha interact, they bring about reciprocal functional changes, so that the activity of HIF-1 alpha is decreased and that of C/EBP alpha is restricted or increased in a tissue-specific manner. This Journal Club article highlights research depicting interactions between HIF-1 alpha and C/EBP alpha and discusses conditions and tissues in which this interaction might occur.
Related Concept Videos
Interpreting ¹H NMR Signal Splitting: The (n + 1) Rule
Hedgehog Signaling Pathway
Hedgehog Signaling Pathway
Catenins
Catenins in Cell Junctions
Catenins bind to cell adhesion molecules such as cadherins and link them to different cytoskeletal proteins depending on the type of cell junction. At the adherens...
Allosteric Proteins-ATCase
Aspartate transcarbamoylase (ATCase) is a cytosolic enzyme that catalyzes the condensation of L-aspartate and carbamoyl phosphate to N-carbamoyl-L-aspartate. This reaction is the first step in pyrimidine biosynthesis. UTP and CTP, the end products of the pyrimidine synthesis pathway,...
C4 Pathway and CAM
C4 Pathway
The C4 pathway is used by plants such as...

