Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Development of the Lymphatic System01:15

Development of the Lymphatic System

601
The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
601
Functions of the Lymphatic and Immune System01:28

Functions of the Lymphatic and Immune System

2.7K
The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
2.7K
Lymphatic Vessels and Lymph Transport01:16

Lymphatic Vessels and Lymph Transport

2.7K
Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular...
2.7K
Introduction to Lymphatic and Immune System01:22

Introduction to Lymphatic and Immune System

2.6K
Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are...
2.6K
Detailed Structure and Function of Lymph Nodes01:23

Detailed Structure and Function of Lymph Nodes

1.4K
Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
1.4K
Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

1.0K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The IBEX knowledge-base a community resource enabling adoption and development of immunofluorescence imaging methods.

eLife·2026
Same author

Epigenetic dysregulation of energy homeostasis drives aortic valve stenosis that is treatable with metformin.

JCI insight·2025
Same author

The IBEX Knowledge-Base: A central resource for multiplexed imaging techniques.

PLoS biology·2025
Same author

Prior SARS-CoV-2 infection affects adaptive immune responses to Omicron BA.4/BA.5 mRNA booster.

The Journal of allergy and clinical immunology·2025
Same author

The IBEX Imaging Knowledge-Base: A Community Resource Enabling Adoption and Development of Immunofluoresence Imaging Methods.

ArXiv·2025
Same author

A spatial human thymus cell atlas mapped to a continuous tissue axis.

Nature·2024
Same journal

Diagnostic Tests for Stage B Heart Failure.

Current cardiology reports·2026
Same journal

Cardioimmunology of Myocarditis: Targeting the IL-1 Pathway.

Current cardiology reports·2026
Same journal

Antithrombotic Management in Patients with Chronic Coronary Syndrome Receiving Oral Anticoagulation.

Current cardiology reports·2026
Same journal

Transcriptome Reprogramming in Heart Failure: The Hidden Splicing Code.

Current cardiology reports·2026
Same journal

Diagnosis and Management of Loeys-Dietz Syndrome: Evidence Gaps and Future Directions.

Current cardiology reports·2026
Same journal

Correction: Heart Disease in Older Women: Unique Challenges in Diagnosis and Management.

Current cardiology reports·2026
See all related articles

Related Experiment Video

Updated: Jun 15, 2025

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

14.3K

Lymphatic System Development and Function.

Harish P Janardhan1,2, Brianna T Wachter1,2,3, Chinmay M Trivedi4,5,6,7

  • 1Division of Cardiovascular Medicine, UMass Chan Medical School, Worcester, MA, 01605, USA.

Current Cardiology Reports
|August 22, 2024
PubMed
Summary
This summary is machine-generated.

Recent advancements reveal diverse lymphatic development and anomalies. Understanding organ-specific lymphatic cell functions is key to treating lymphatic malformations and advancing personalized medicine.

Keywords:
Lymphatic developmentLymphatic malformationOrgan-specific lymphatic function

More Related Videos

Digestion of the Murine Liver for a Flow Cytometric Analysis of Lymphatic Endothelial Cells
08:07

Digestion of the Murine Liver for a Flow Cytometric Analysis of Lymphatic Endothelial Cells

Published on: January 7, 2019

10.8K
Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice
05:59

Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice

Published on: May 14, 2020

6.4K

Related Experiment Videos

Last Updated: Jun 15, 2025

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

14.3K
Digestion of the Murine Liver for a Flow Cytometric Analysis of Lymphatic Endothelial Cells
08:07

Digestion of the Murine Liver for a Flow Cytometric Analysis of Lymphatic Endothelial Cells

Published on: January 7, 2019

10.8K
Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice
05:59

Blocking Lymph Flow by Suturing Afferent Lymphatic Vessels in Mice

Published on: May 14, 2020

6.4K

Area of Science:

  • Developmental Biology
  • Genetics
  • Medical Science

Background:

  • The lymphatic system is crucial for fluid homeostasis and immune surveillance.
  • Lymphatic malformations can lead to severe health complications.
  • Understanding lymphatic development is essential for disease management.

Purpose of the Study:

  • To review recent advancements in generalized and organ-specific lymphatic development.
  • To highlight critical anomalies impairing lymphatic function.
  • To explore developmental mechanisms and the impact of lymphatic malformations.

Main Methods:

  • Genome sequencing
  • Single-cell transcriptomic analysis
  • Advanced imaging technologies

Main Results:

  • New technologies have improved identification of lymphatic developmental defects.
  • A spectrum of lymphatic anomalies, from congenital to life-threatening, has been uncovered.
  • Research shows lymphatic heterogeneity with organ-specific pathways and functions.

Conclusions:

  • Understanding organ-specific lymphatic cell populations is vital for lymphatic disease research.
  • Personalized medicine approaches for lymphatic disorders can be revolutionized through translational research.
  • Tailored treatments based on individual lymphatic profiles promise enhanced efficacy and reduced side effects.