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Updated: Jun 28, 2026

A Mouse Model of Hemorrhagic Transformation Induced by Acute Hyperglycemia Combined with Transient Focal Ischemia
Published on: November 15, 2024
Cardiovascular effects of acute hyperglycaemia: pathophysiological underpinnings
1Warwick Medical School, Clinical Science Research Institute, University Hospital -Coventry, CV2 2DX, UK. antonio.ceriello@warwick.ac.uk
Abstract:
High admission blood glucose levels after acute myocardial infarction are common and are associated with an increased risk of death in subjects with and without diabetes. In this review, the possible toxic effects of acute hyperglycaemia are discussed as a possible explanation for the worse prognosis in subjects with myocardial infarction and concomitant hyperglycaemia. In particular, evidence supporting the hypothesis that acute hyperglycaemia may favour the appearance of cardiovascular disease through the generation of oxidative stress is presented.
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