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Manufacture and Drug Delivery Applications of Silk Nanoparticles
Published on: October 8, 2016
Nanoparticle formulations in pulmonary drug delivery
Mark M Bailey1, Cory J Berkland
1Department of Chemical & Petroleum Engineering, The University of Kansas, Lawrence, KS 66047, USA.
Medicinal Research Reviews
|October 30, 2008
Summary
Nanotechnology offers advanced lung drug delivery using nanoparticles for enhanced treatment. Various nanoparticle formulations show promise, but production challenges and safety require further investigation.
Area of Science:
- Pulmonary drug delivery
- Nanotechnology applications in medicine
- Pharmaceutical formulation science
Background:
- The lungs present a large surface area and minimal barriers, making them an ideal route for drug delivery.
- Nanoparticles offer novel formulation options for inhaled therapies, improving drug dissolution and enabling intracellular delivery.
- Traditional dosage forms face limitations that nanoparticles can potentially overcome.
Purpose of the Study:
- To review the benefits and progress of nanoparticle formulations for pulmonary drug delivery.
- To compare various nanoparticle types and production methods for lung delivery.
- To address practical challenges and toxicological concerns associated with nanoparticle pulmonary delivery.
Main Methods:
- Review of current literature on nanoparticle formulations for pulmonary delivery.
- Comparison of different nanoparticle types (e.g., pure drug, polymeric, liposomes) and their properties.
- Analysis of traditional and advanced manufacturing techniques for nanoparticle production.
Main Results:
- Nanoparticle formulations demonstrate enhanced dissolution and potential for intracellular drug delivery compared to traditional forms.
- Various nanoparticle types, including pure drug nanoparticles, polymeric nanoparticles, polyelectrolyte complexes, and liposomes, show encouraging results.
- Several methods, from spray drying to supercritical fluid extraction, are used to produce nanoparticles for lung delivery.
Conclusions:
- Nanoparticle-based pulmonary drug delivery holds significant therapeutic potential due to enhanced efficacy and targeted delivery.
- Further research is needed to optimize nanoparticle production processes and fully assess toxicological profiles for safe clinical application.
- Overcoming manufacturing hurdles is crucial for the widespread adoption of nanotechnology in lung-targeted therapies.
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