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Related Experiment Video

Updated: Jun 28, 2026

Multidisciplinary Approach to Obesity Management: A Case Report

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

Sibutramine-associated psychosis (case report).

Gábor Gazdag¹, Zsuzsa Szabó

¹Szent László Hospital, Consultation-Liaison Psychiatric Service, Budapest, Hungary. gazdag@lamb.hu

Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet Lapja = Official Journal of the Hungarian Association of Psychopharmacology

|October 31, 2008

Summary

Sibutramine, an appetite suppressant, may induce psychotic episodes in vulnerable individuals. A case study showed a patient experienced psychosis after three weeks of use, with symptoms resolving upon discontinuation.

Related Experiment Videos

Last Updated: Jun 28, 2026

Multidisciplinary Approach to Obesity Management: A Case Report

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

Area of Science:

Psychiatry
Pharmacology
Clinical Medicine

Background:

Sibutramine is an appetite suppressant with a known association with psychotic episodes.
Four previous cases of psychosis linked to sibutramine exist in medical literature.

Observation:

A 39-year-old woman developed a psychotic state after three weeks of taking 10 mg/day sibutramine for weight loss.
Her symptoms included behavioral changes, task neglect, and unrealistic thoughts, resolving spontaneously two weeks after stopping the drug.

Findings:

The patient's history of severe life difficulties likely compromised her psychological defenses, increasing vulnerability to sibutramine's psychosis-inducing effects.
The Naranjo Adverse Drug Reaction scale indicated a probable correlation between sibutramine use and the observed psychotic symptoms.

Implications:

Individuals with pre-existing psychological vulnerabilities or high stress levels should use sibutramine with extreme caution and under strict medical supervision.
This case highlights the importance of considering psychiatric side effects when prescribing appetite suppressants like sibutramine.