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Updated: Jun 28, 2026
05:45
Diagnosis of Hirschsprung's Disease by Immunostaining Rectal Suction Biopsies for Calretinin, S100 Protein and Protein Gene Product 9.5
Published on: April 26, 2019
Hirschsprung's disease: a regional experience.
Cherry E Koh1, Tuck L Yong, Edmond J M Fenton
1Women's and Children's Services, Royal Hobart Hospital, Hobart, Tasmania, Australia. cherry_koh@hotmail.com
ANZ Journal of Surgery
|October 31, 2008
Summary
The incidence of Hirschsprung
Area of Science:
- Pediatric Surgery
- Gastroenterology
- Epidemiology
Background:
- Hirschsprung's disease (HD) incidence is typically cited as 1 in 5000 live births.
- Regional variations in Hirschsprung's disease incidence are known to occur.
- This study investigates the incidence and regional experience of HD in Tasmania.
Purpose of the Study:
- To determine the incidence of Hirschsprung's disease in Tasmania.
- To document the regional experience and presentation of HD cases in Tasmania.
Main Methods:
- Retrospective review of newly diagnosed Hirschsprung's disease cases (1998-2005).
- Data extracted from medical records and cross-referenced with Tasmanian birth statistics.
- Incidence calculated using Australian Bureau of Statistics data.
Main Results:
- 14 new cases of Hirschsprung's disease identified in Tasmania over 8 years.
- Estimated incidence in Tasmania: 1 in 3429 live births, higher than the general quote.
- A surge in cases (11/14) occurred between 2003-2005, with no clear explanation; common presentations included abdominal distension and vomiting; delayed meconium passage noted in 43%.
Conclusions:
- The incidence of Hirschsprung's disease appears higher in Tasmania than previously reported.
- An unexplained surge in HD cases was observed between 2003 and 2005.
- Delayed passage of meconium was less frequent than cited in prior literature.
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