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New colorimetric method for the determination of nystatin

M M Amer¹, A A Habeeb

¹Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt.

|July 1, 1975

Abstract:

A new colorimetric method for the determination of nystatin is reported, based on the reaction of the alkaline hydrolysis product of nystatin with p-aminoacetophenone in presence of concentrated hydrochloric acid. The proposed method determines 0.2-1.0mg of nystatin with recovery of 100.7 +/- 1.2%. The method is adopted to the determination of nystatin in pharmaceutical preparations, and interference due to the presence of sugar is eliminated.

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