Related Experiment Video
Updated: Jun 28, 2026

Double-barreled and Concentric Microelectrodes for Measurement of Extracellular Ion Signals in Brain Tissue
Published on: September 5, 2015
Limits of detection and selectivity coefficients of liquid membrane electrodes
N Kamo1, N Hazemoto, Y Kobatake
1Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Abstract:
An equation has been derived theoretically describing the emf of a liquid membrane electrode: E = E(0) - (RT/F) ln[(C + radicalC (2) + A (x))/2]. Experimental data are in good agreement with this equation. The parameter A(x) is related to the limit of detection. When the ion-exchanger dissociates completely in the membrane phase, A(x) is given by 4sigma(2)/b(x). Here sigma represents the concentration of the ion-exchanger in the liquid membrane and b(x) is a quantity related to the ion-selectivity.
Related Concept Videos
Potentiometry: Membrane Electrodes
High-Performance Liquid Chromatography: Types of Detectors
Difference from Background: Limit of Detection
The LOD indicates the presence or absence...
Gas Chromatography: Overview of Detectors
A non-destructive detector allows a sample to be analyzed without altering or consuming it, meaning the sample can be collected after detection for further analysis. Examples include thermal conductivity detectors and...
Potentiometry: Types of Electrodes
The Standard Hydrogen Electrode (SHE) is a widely used reference electrode that maintains zero potential across all temperatures. However, its need for a continuous hydrogen gas supply renders it impractical for everyday use.
An alternative to SHE is the Saturated Calomel Electrode (SCE). This electrode features an...
Capillary Electrophoresis: Applications
Capillary zone electrophoresis (CZE) separates ionic components based on their electrophoretic mobility. It has been used to separate proteins, amino acids,...
