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Potentiometric Titration: Overview01:31

Potentiometric Titration: Overview

Potentiometric titration is a quantitative analytical technique that determines the concentration of an analyte by measuring the potential difference between the two electrodes in the solution. The endpoint of a potentiometric titration is the point at which there is a significant change in the potential difference. It occurs when the stoichiometric reaction between the analyte and the titrant is complete. The endpoint is usually determined graphically by plotting the measured potential...
Complexometric EDTA Titration Curves01:20

Complexometric EDTA Titration Curves

EDTA titration curves determine the free metal ion concentration. The titration curve represents the change in concentration of free metal ions (p function) as a function of the volume of EDTA added. This curve consists of three regions: before, at, and after equivalence points. Excess free metal ions are present before the equivalence point. Equal concentrations of metal ions and EDTA are present at the equivalence point. After the equivalence point, excess EDTA exists. This means slight...
EDTA: Indirect and Alkalimetric Titration01:23

EDTA: Indirect and Alkalimetric Titration

Unlike direct titration, back-titration, and displacement titration, indirect titration is an EDTA titration method for quantifying anions. In the indirect titration method, anions are precipitated as their insoluble salts with excess metal ions. The filtrate containing the excess metal ions is directly titrated with standard EDTA until the endpoint is achieved. Another approach involves extracting the metal ion and back-titrating with standard EDTA to obtain the endpoint. In this way, the...
Redox Titration: Iodimetry and Iodometry01:23

Redox Titration: Iodimetry and Iodometry

Iodometry and iodimetry are analytical methods used to determine the concentration of oxidizing or reducing agents using iodine. In iodometric titrations, the oxidizing analyte solution is usually acidified and treated with an excess of iodide ions, which generates an equivalent amount of iodine in equilibrium with triiodide. The released iodine is subsequently titrated directly against a standardized reducing agent. As the dilute iodine color becomes pale yellow, a few drops of freshly...
Complexometric Titration: Overview00:39

Complexometric Titration: Overview

Complexometric titration involves the formation of a complex by reacting a metal ion with one or more ligands. A visual indicator often detects the end point of a complexometric titration. It is added to the metal solution before the titration, forming a stable metal–indicator complex and imparting color to the solution. As the titration approaches the equivalence point, the excess of the added ligand displaces the indicator from the metal–indicator complex, releasing the free indicator. The...
Redox Titration: Overview01:21

Redox Titration: Overview

Redox titration is a chemical analysis technique used to determine the concentration of an unknown substance by measuring the electron transfer in a redox (reduction-oxidation) reaction. The process involves gradually adding a titrant with a known concentration of an oxidizing or reducing agent, to the analyte, the solution with an unknown concentration, until reaching the endpoint, which indicates the completion of the reaction between the two substances. Ensuring the analyte is in a single...

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Related Experiment Video

Updated: Jun 28, 2026

Titration ELISA as a Method to Determine the Dissociation Constant of Receptor Ligand Interaction
12:38

Titration ELISA as a Method to Determine the Dissociation Constant of Receptor Ligand Interaction

Published on: February 15, 2018

Linear titration plots with ion-selective electrodes.

A Ivaska1

  • 1Department of Analytical Chemistry, Abo Akademi, 20500 Abo 50, Finland.

Talanta
|February 1, 1980
PubMed
Summary
This summary is machine-generated.

A new computational method accurately determines ion-selective electrode parameters. This approach simplifies data analysis for titration and standard addition, achieving precise results with minimal error.

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Area of Science:

  • Analytical Chemistry
  • Electrochemistry
  • Computational Chemistry

Background:

  • Ion-selective electrodes (ISEs) are crucial for chemical analysis.
  • Accurate determination of equivalence volume and Nernstian slope is essential for ISE performance.
  • Current data analysis methods can be complex and time-consuming.

Purpose of the Study:

  • To develop a simplified computational method for simultaneous determination of equivalence volume and Nernstian slope.
  • To improve the efficiency and accuracy of data analysis for ISEs.
  • To reduce errors in determining ISE parameters.

Main Methods:

  • A novel computational approach was applied to analyze titration and standard addition data.
  • The method utilizes equal additions of standard solution to simplify data treatment.
  • Simultaneous calculation of equivalence volume and Nernstian slope was performed.

Main Results:

  • The proposed computational method allows for the simultaneous determination of equivalence volume and Nernstian slope.
  • Data treatment for linear titration and standard addition procedures is significantly simplified.
  • Equivalence volumes and concentrations were determined with high accuracy, showing errors between 0.5% and 2%.

Conclusions:

  • The developed computational method offers a robust and efficient way to analyze ISE data.
  • This technique enhances the precision of determining key ISE parameters.
  • The method is suitable for routine analysis and research involving ion-selective electrodes.