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Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

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Related Experiment Video

Updated: Jun 28, 2026

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
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Published on: April 14, 2014

Opticospinal multiple sclerosis in Iran.

Hossein Kalanie1, Yadollah Kholghie, Gholam-Reza Shamsai

  • 1Department of Neurology, Loghman Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. hkalanie@yahoo.com

Journal of the Neurological Sciences
|October 31, 2008
PubMed
Summary
This summary is machine-generated.

This study on opticospinal multiple sclerosis (MS) found a 3.8% prevalence. Patients exhibited a relapsing-remitting course with spinal or optic nerve involvement, and distinct MRI patterns without brainstem or enhanced lesions.

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Modeling Multiple Sclerosis in the Two Sexes: MOG35-55-Induced Experimental Autoimmune Encephalomyelitis
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Published on: October 13, 2023

Area of Science:

  • Neurology
  • Neuroimmunology
  • Clinical Neuroscience

Background:

  • Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system.
  • Opticospinal MS is a subtype characterized by initial optic nerve and spinal cord involvement.
  • Understanding the clinical and imaging characteristics of MS subtypes is crucial for diagnosis and management.

Purpose of the Study:

  • To review the clinical course, MRI findings, and CSF data of patients with opticospinal MS.
  • To determine the prevalence and characteristics of this MS subtype.

Main Methods:

  • Retrospective review of 20 patients with clinically definite MS and opticospinal presentation.
  • Analysis of clinical data, including age of onset, gender, and disease duration.
  • Evaluation of MRI scans (brain and spinal cord) and cerebrospinal fluid (CSF) analysis.

Main Results:

  • Prevalence of opticospinal MS was 3.8% among definite MS cases.
  • All patients had a relapsing-remitting course with a mean age of onset of 24 years.
  • Initial presentation involved spinal signs (60%) or optic neuritis (35%); no transverse myelitis or brainstem signs were observed.
  • MRI revealed T2 lesions in the brain (periventricular, juxtacortical) but not gadolinium-enhanced lesions. Spinal cord lesions were common.
  • CSF showed normal cell/protein counts and negative oligoclonal bands.

Conclusions:

  • Opticospinal MS presents with a relapsing-remitting course and distinct MRI findings.
  • The absence of certain lesions and negative CSF findings may differentiate this subtype.
  • Further research is needed to fully characterize opticospinal MS and its long-term prognosis.