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Anodic polarographic determination of flucloxacillin
J A Squella1, M M Silva, L J Nuñez-Vergara
1Department of Chemical Pharmacology and Physical Chemistry, Faculty of Chemical and Pharmacological Sciences, P.O. Box 233, Santiago, Chile.
Talanta
|November 1, 1981
Abstract:
The hydrolysis of flucloxacillin at pH 4.9 yields a degradation product which is polarographically oxidizable. This derivative has not been identified, but would seem to contain a thiol group. It gives a diffusion-controlled anodic polarographic wave with a half-wave potential at -0.24 V vs. SCE. The method developed has been applied to the analysis of flucloxacillin capsules, and a recovery of 99% has been obtained.
